Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3908464..3909063 Replicon chromosome
Accession NZ_CP040441
Organism Alkalihalobacillus halodurans isolate LB-1

Toxin (Protein)


Gene name mazF Uniprot ID Q9K6K8
Locus tag FED51_RS19035 Protein ID WP_010899846.1
Coordinates 3908734..3909063 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M0KGU6
Locus tag FED51_RS19030 Protein ID WP_041820955.1
Coordinates 3908464..3908733 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FED51_RS19020 3904662..3905543 - 882 WP_053430185.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
FED51_RS19025 3905559..3907385 - 1827 WP_053430184.1 polysaccharide biosynthesis protein -
FED51_RS19030 3908464..3908733 + 270 WP_041820955.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FED51_RS19035 3908734..3909063 + 330 WP_010899846.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FED51_RS21235 3909785..3909925 + 141 WP_010899847.1 hypothetical protein -
FED51_RS19040 3910179..3910823 - 645 WP_053430183.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
FED51_RS19045 3910834..3911787 - 954 WP_053430182.1 sugar kinase -
FED51_RS19050 3911854..3912609 - 756 WP_053430181.1 IclR family transcriptional regulator -
FED51_RS19055 3912866..3913324 - 459 WP_053430180.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-107)

Antitoxin

SpoVT-AbrB domain

(16-61)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12139.93 Da        Isoelectric Point: 6.7069

>T125805 WP_010899846.1 NZ_CP040441:3908734-3909063 [Alkalihalobacillus halodurans]
MPVPDRGNLVYVDFNPQSGHDQAGTRPAIVLSPKLFNKNTGFAVVCPITRQQKGYPFEIEIPPGLPIEGVILTDQVKSLD
WRARNFHIKGQAPEETVTDCLQLIHTFLS

Download         Length: 330 bp

>T125805 NZ_CP040441:3908734-3909063 [Alkalihalobacillus halodurans]
ATGCCAGTACCGGATAGAGGGAATCTTGTTTATGTAGACTTTAACCCACAATCGGGTCATGACCAAGCCGGGACACGACC
GGCTATTGTTTTGTCCCCTAAATTATTTAATAAAAACACAGGTTTTGCGGTGGTTTGTCCAATTACCAGACAACAAAAAG
GTTATCCTTTTGAAATAGAAATACCACCGGGGTTACCTATTGAAGGGGTTATTCTTACTGACCAAGTAAAAAGTCTGGAT
TGGAGAGCAAGAAACTTTCACATTAAAGGACAAGCACCAGAGGAAACTGTTACTGATTGTTTACAACTTATTCATACATT
TTTATCTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10048.56 Da        Isoelectric Point: 9.7279

>AT125805 WP_041820955.1 NZ_CP040441:3908464-3908733 [Alkalihalobacillus halodurans]
MNVDENKGVTLMTTIQKWGNSLAVRIPNHYAKHINVTQGSEIELSLGSDQTIILKPKKRKPTLEELVAKITPENRHNEID
FGRTGKELL

Download         Length: 270 bp

>AT125805 NZ_CP040441:3908464-3908733 [Alkalihalobacillus halodurans]
ATGAATGTAGATGAAAATAAAGGAGTGACACTCATGACTACTATACAAAAGTGGGGAAATAGTTTAGCTGTTCGTATTCC
GAACCATTATGCTAAACATATTAACGTTACGCAAGGATCTGAAATTGAACTAAGCTTAGGGAGTGATCAAACGATTATTT
TAAAGCCTAAAAAAAGAAAGCCAACATTAGAGGAATTAGTGGCAAAAATCACTCCTGAAAACAGACATAACGAAATTGAT
TTCGGGAGAACAGGAAAGGAATTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K6K8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M0KGU6

References