Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 713089..713579 Replicon chromosome
Accession NZ_CP040420
Organism Dolosigranulum pigrum strain KPL3065

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE325_RS03365 Protein ID WP_004636454.1
Coordinates 713313..713579 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE325_RS03360 Protein ID WP_004636455.1
Coordinates 713089..713316 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE325_RS03350 (FE325_03365) 708272..710125 + 1854 WP_208953663.1 oligopeptide ABC transporter substrate-binding protein -
FE325_RS03355 (FE325_03370) 710202..712754 - 2553 WP_208953664.1 transglycosylase domain-containing protein -
FE325_RS03360 (FE325_03375) 713089..713316 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE325_RS03365 (FE325_03380) 713313..713579 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE325_RS03370 (FE325_03385) 713691..714656 - 966 WP_208953665.1 rhodanese-related sulfurtransferase -
FE325_RS03375 (FE325_03390) 714792..716597 - 1806 WP_208953666.1 M3 family oligoendopeptidase -
FE325_RS03380 (FE325_03395) 716751..717218 - 468 WP_208953667.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125765 WP_004636454.1 NZ_CP040420:713313-713579 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125765 NZ_CP040420:713313-713579 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGATGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125765 WP_004636455.1 NZ_CP040420:713089-713316 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125765 NZ_CP040420:713089-713316 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References