Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2028667..2029498 Replicon chromosome
Accession NZ_CP040390
Organism Escherichia coli strain A1_136

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FE198_RS09945 Protein ID WP_000854814.1
Coordinates 2028667..2029041 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FE198_RS09950 Protein ID WP_001285585.1
Coordinates 2029130..2029498 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE198_RS09905 2024063..2025229 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FE198_RS09910 2025348..2025821 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
FE198_RS09915 2026019..2027077 + 1059 WP_001200891.1 FUSC family protein -
FE198_RS09920 2027249..2027578 + 330 WP_000450409.1 DUF496 family protein -
FE198_RS09925 2027679..2027861 - 183 WP_001016348.1 hypothetical protein -
FE198_RS09930 2027933..2028061 + 129 Protein_1910 transposase domain-containing protein -
FE198_RS09935 2028350..2028463 - 114 WP_001161660.1 DUF957 domain-containing protein -
FE198_RS09940 2028476..2028670 - 195 WP_000988600.1 hypothetical protein -
FE198_RS09945 2028667..2029041 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FE198_RS09950 2029130..2029498 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FE198_RS09955 2029572..2029793 - 222 WP_000692323.1 DUF987 domain-containing protein -
FE198_RS09960 2029856..2030332 - 477 WP_039267628.1 RadC family protein -
FE198_RS09965 2030348..2030827 - 480 WP_000860087.1 antirestriction protein -
FE198_RS09970 2030909..2031727 - 819 WP_060626401.1 DUF945 domain-containing protein -
FE198_RS09980 2031827..2032060 - 234 WP_001119729.1 DUF905 family protein -
FE198_RS09985 2032135..2032590 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T125663 WP_000854814.1 NZ_CP040390:c2029041-2028667 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T125663 NZ_CP040390:c2029041-2028667 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT125663 WP_001285585.1 NZ_CP040390:c2029498-2029130 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT125663 NZ_CP040390:c2029498-2029130 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References