Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2574663..2575320 Replicon chromosome
Accession NZ_CP040363
Organism Klebsiella pneumoniae strain R50

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FEM43_RS12950 Protein ID WP_002916310.1
Coordinates 2574910..2575320 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FEM43_RS12945 Protein ID WP_002916312.1
Coordinates 2574663..2574929 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM43_RS12920 2569819..2571252 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FEM43_RS12925 2571371..2572099 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FEM43_RS12930 2572149..2572460 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FEM43_RS12935 2572624..2573283 + 660 WP_002916317.1 hemolysin III family protein -
FEM43_RS12940 2573434..2574417 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FEM43_RS12945 2574663..2574929 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FEM43_RS12950 2574910..2575320 + 411 WP_002916310.1 protein YgfX Toxin
FEM43_RS12955 2575327..2575848 - 522 WP_002916308.1 flavodoxin FldB -
FEM43_RS12960 2575949..2576845 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FEM43_RS12965 2576868..2577581 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FEM43_RS12970 2577587..2579320 + 1734 WP_142778400.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T125640 WP_002916310.1 NZ_CP040363:2574910-2575320 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T125640 NZ_CP040363:2574910-2575320 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT125640 WP_002916312.1 NZ_CP040363:2574663-2574929 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT125640 NZ_CP040363:2574663-2574929 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References