Detailed information of TA system TA125346

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 5219184..5219405
• Replicon: chromosome
• Accession: NZ_CP040307
• Organism: Escherichia coli strain F1 E4

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: FEL01_RS25885
• Protein ID: WP_001295224.1
• Coordinates: 5219184..5219291 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	5219340..5219405 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL01_RS25860	5214437..5215189	-	753	Protein_5036	cellulose biosynthesis protein BcsQ	-
FEL01_RS25865	5215201..5215389	-	189	WP_001063316.1	YhjR family protein	-
FEL01_RS25870	5215662..5217233	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
FEL01_RS25875	5217230..5217421	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FEL01_RS25880	5217418..5219097	+	1680	WP_000191592.1	cellulose biosynthesis protein BcsG	-
FEL01_RS25885	5219184..5219291	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	5219340..5219405	+	66	NuclAT_17	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_17	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_17	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_17	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_22	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_22	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_22	-	Antitoxin
-	5219340..5219405	+	66	NuclAT_22	-	Antitoxin
FEL01_RS25890	5219767..5221038	+	1272	WP_001301684.1	amino acid permease	-
FEL01_RS25895	5221068..5222072	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FEL01_RS25900	5222069..5223052	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FEL01_RS25905	5223063..5223965	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T125346 WP_001295224.1 NZ_CP040307:c5219291-5219184 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T125346 NZ_CP040307:c5219291-5219184 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT125346 NZ_CP040307:5219340-5219405 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin