Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2071881..2073430 Replicon chromosome
Accession NZ_CP040243
Organism Glaesserella parasuis strain HPS-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FEF05_RS10450 Protein ID WP_149351190.1
Coordinates 2071881..2073197 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag FEF05_RS10455 Protein ID WP_010786623.1
Coordinates 2073191..2073430 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEF05_RS10410 2067095..2067682 + 588 WP_075621022.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
FEF05_RS10415 2067938..2068117 - 180 Protein_1985 disulfide bond formation protein DsbA -
FEF05_RS10420 2068117..2068587 - 471 WP_149351188.1 nuclear transport factor 2 family protein -
FEF05_RS10425 2068694..2068810 + 117 Protein_1987 LysR family transcriptional regulator -
FEF05_RS10430 2068891..2069464 - 574 Protein_1988 virulence RhuM family protein -
FEF05_RS10435 2069651..2070010 - 360 WP_010787368.1 hypothetical protein -
FEF05_RS10440 2070127..2070312 + 186 WP_149351189.1 hypothetical protein -
FEF05_RS10445 2070624..2071877 + 1254 WP_149351312.1 PLP-dependent aminotransferase family protein -
FEF05_RS10450 2071881..2073197 - 1317 WP_149351190.1 type II toxin-antitoxin system HipA family toxin Toxin
FEF05_RS10455 2073191..2073430 - 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
FEF05_RS10460 2073578..2074405 - 828 WP_035493932.1 alpha/beta hydrolase -
FEF05_RS10465 2074536..2075981 + 1446 WP_149351191.1 metalloprotease TldD -
FEF05_RS10470 2076236..2076646 + 411 WP_005713295.1 preprotein translocase subunit SecE -
FEF05_RS10475 2076648..2077226 + 579 WP_005713298.1 transcription termination/antitermination protein NusG -
FEF05_RS10480 2077352..2077606 - 255 WP_005713300.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49997.27 Da        Isoelectric Point: 7.6047

>T125175 WP_149351190.1 NZ_CP040243:c2073197-2071881 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMAKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNSKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNPNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1317 bp

>T125175 NZ_CP040243:c2073197-2071881 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTTTTTGATAATTTACTGCCCGATAATCCTCAAATTAGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGATTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGGCGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAAACA
GCTCTGCTTTGGCATAACAGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATCCCAACGATCGTC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACATGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGCACGCAAAAAGGAAAAAAATGGCATTGGAGTAAAATTTATGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT125175 WP_010786623.1 NZ_CP040243:c2073430-2073191 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT125175 NZ_CP040243:c2073430-2073191 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TTAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References