Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 810637..811172 Replicon chromosome
Accession NZ_CP040243
Organism Glaesserella parasuis strain HPS-1

Toxin (Protein)


Gene name relE Uniprot ID B8F327
Locus tag FEF05_RS04160 Protein ID WP_012621505.1
Coordinates 810888..811172 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag FEF05_RS04155 Protein ID WP_010785924.1
Coordinates 810637..810891 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEF05_RS04140 807633..808529 + 897 WP_075605808.1 ABC transporter ATP-binding protein -
FEF05_RS04145 808551..809306 + 756 WP_012621503.1 ABC transporter permease -
FEF05_RS04150 809434..810531 + 1098 WP_012621948.1 ISAs1 family transposase -
FEF05_RS04155 810637..810891 + 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
FEF05_RS04160 810888..811172 + 285 WP_012621505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEF05_RS04165 811381..812931 + 1551 WP_149350782.1 exodeoxyribonuclease I -
FEF05_RS04170 813014..813973 + 960 WP_149350783.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
FEF05_RS04175 814121..814942 + 822 WP_149350784.1 PHP domain-containing protein -
FEF05_RS04180 815048..815539 - 492 WP_016528224.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11257.23 Da        Isoelectric Point: 10.4221

>T125170 WP_012621505.1 NZ_CP040243:810888-811172 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
REHNDVYQKVQLRL

Download         Length: 285 bp

>T125170 NZ_CP040243:810888-811172 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTATATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCACAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT125170 WP_010785924.1 NZ_CP040243:810637-810891 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT125170 NZ_CP040243:810637-810891 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B8F327

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References