Detailed information of TA system TA125162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1066176..1066784
• Replicon: chromosome
• Accession: NZ_CP040235
• Organism: Bifidobacterium longum strain ZJ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3BGL7
• Locus tag: FCE94_RS04685
• Protein ID: WP_007056255.1
• Coordinates: 1066176..1066511 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3BGP0
• Locus tag: FCE94_RS04690
• Protein ID: WP_007056990.1
• Coordinates: 1066515..1066784 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCE94_RS04645	1061273..1061947	+	675	WP_077322431.1	YidC/Oxa1 family membrane protein insertase	-
FCE94_RS04650	1062049..1062669	+	621	WP_007054239.1	NUDIX hydrolase	-
FCE94_RS04655	1062698..1063021	+	324	WP_012471871.1	amidohydrolase	-
FCE94_RS10745	1063185..1063331	-	147	WP_007056267.1	hypothetical protein	-
FCE94_RS10750	1063671..1063964	-	294	WP_012471870.1	hypothetical protein	-
FCE94_RS04665	1064057..1064698	-	642	WP_007056262.1	hypothetical protein	-
FCE94_RS04670	1064912..1065091	+	180	WP_007056286.1	antitoxin VbhA family protein	-
FCE94_RS04675	1065088..1065672	+	585	WP_007056278.1	Fic family protein	-
FCE94_RS04680	1065875..1066159	-	285	WP_007056282.1	hypothetical protein	-
FCE94_RS04685	1066176..1066511	-	336	WP_007056255.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FCE94_RS04690	1066515..1066784	-	270	WP_007056990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FCE94_RS04695	1066969..1068138	-	1170	WP_118068976.1	ABC transporter permease	-
FCE94_RS04700	1068135..1068780	-	646	Protein_871	ABC transporter ATP-binding protein	-
FCE94_RS04705	1068777..1069667	-	891	WP_007056280.1	hypothetical protein	-
FCE94_RS04710	1069664..1070179	-	516	WP_032685213.1	hypothetical protein	-
FCE94_RS04715	1070305..1071000	+	696	WP_003829410.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1043330..1079917	36587

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12650.60 Da
• Isoelectric Point: 9.1088

>T125162 WP_007056255.1 NZ_CP040235:c1066511-1066176 [Bifidobacterium longum]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI

Nucleotide

• Length: 336 bp

>T125162 NZ_CP040235:c1066511-1066176 [Bifidobacterium longum]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.16 Da
• Isoelectric Point: 4.5742

>AT125162 WP_007056990.1 NZ_CP040235:c1066784-1066515 [Bifidobacterium longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT125162 NZ_CP040235:c1066784-1066515 [Bifidobacterium longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Structures

Toxin

• AlphaFold DB: I3BGL7

Antitoxin

• AlphaFold DB: I3BGP0