Detailed information of TA system TA124893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2496..3147
• Replicon: plasmid unnamed2
• Accession: NZ_CP040082
• Organism: Acinetobacter baumannii strain SP304

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V2UF49
• Locus tag: FDM99_RS18280
• Protein ID: WP_000269909.1
• Coordinates: 2496..2852 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FDM99_RS18285
• Protein ID: WP_001140621.1
• Coordinates: 2845..3147 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDM99_RS18275	1597..1961	+	365	Protein_0	tautomerase family protein	-
FDM99_RS18280	2496..2852	+	357	WP_000269909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDM99_RS18285	2845..3147	+	303	WP_001140621.1	XRE family transcriptional regulator	Antitoxin
FDM99_RS18290	3140..3349	+	210	WP_000069474.1	hypothetical protein	-
FDM99_RS18295	3525..4044	+	520	Protein_4	sel1 repeat family protein	-
FDM99_RS18300	4083..4595	+	513	WP_001089573.1	SMI1/KNR4 family protein	-
FDM99_RS18305	5396..5785	+	390	WP_032040164.1	tautomerase family protein	-
FDM99_RS18310	5961..6502	-	542	Protein_7	plasmid replication DNA-binding protein	-
FDM99_RS18315	6580..7503	-	924	Protein_8	replication initiation protein RepM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9605	9605

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13515.49 Da
• Isoelectric Point: 6.4631

>T124893 WP_000269909.1 NZ_CP040082:2496-2852 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T124893 NZ_CP040082:2496-2852 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11179.02 Da
• Isoelectric Point: 7.3198

>AT124893 WP_001140621.1 NZ_CP040082:2845-3147 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT124893 NZ_CP040082:2845-3147 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Structures

Toxin

• AlphaFold DB: V2UF49