Detailed information of TA system TA124844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2183332..2184011
• Replicon: chromosome
• Accession: NZ_CP040050
• Organism: Acinetobacter baumannii strain VB16141

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FDF20_RS10605
• Protein ID: WP_000838146.1
• Coordinates: 2183829..2184011 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FDF20_RS10600
• Protein ID: WP_000966688.1
• Coordinates: 2183332..2183736 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDF20_RS10595	2182723..2183232	-	510	WP_000735548.1	hypothetical protein	-
FDF20_RS10600	2183332..2183736	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FDF20_RS10605	2183829..2184011	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FDF20_RS10615	2184336..2184851	-	516	WP_009517104.1	hypothetical protein	-
FDF20_RS10620	2184921..2185838	-	918	WP_042774720.1	hypothetical protein	-
FDF20_RS10625	2185891..2186862	-	972	WP_045544023.1	hypothetical protein	-
FDF20_RS10630	2186862..2187215	-	354	WP_002055486.1	hypothetical protein	-
FDF20_RS10635	2187312..2187833	-	522	WP_002055493.1	SH3 domain-containing protein	-
FDF20_RS10640	2187942..2188160	-	219	WP_002132566.1	hypothetical protein	-
FDF20_RS10645	2188162..2188560	-	399	WP_045544022.1	hypothetical protein	-
FDF20_RS10650	2188562..2188930	-	369	WP_032016325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2157350..2214440	57090

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T124844 WP_000838146.1 NZ_CP040050:c2184011-2183829 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T124844 NZ_CP040050:c2184011-2183829 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT124844 WP_000966688.1 NZ_CP040050:c2183736-2183332 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT124844 NZ_CP040050:c2183736-2183332 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6