Detailed information of TA system TA124842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 891246..891925
• Replicon: chromosome
• Accession: NZ_CP040050
• Organism: Acinetobacter baumannii strain VB16141

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FDF20_RS04390
• Protein ID: WP_000838146.1
• Coordinates: 891246..891428 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FDF20_RS04395
• Protein ID: WP_000966688.1
• Coordinates: 891521..891925 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDF20_RS04345	886581..886985	+	405	WP_045544425.1	hypothetical protein	-
FDF20_RS04350	886957..887325	+	369	WP_001993865.1	hypothetical protein	-
FDF20_RS04355	887327..887725	+	399	WP_002062850.1	hypothetical protein	-
FDF20_RS04360	887727..887945	+	219	WP_002002228.1	hypothetical protein	-
FDF20_RS04365	888041..888394	+	354	WP_032051762.1	hypothetical protein	-
FDF20_RS04370	888394..889365	+	972	WP_032051761.1	hypothetical protein	-
FDF20_RS04375	889418..890335	+	918	WP_000094273.1	hypothetical protein	-
FDF20_RS04380	890405..890920	+	516	WP_001185592.1	hypothetical protein	-
FDF20_RS04390	891246..891428	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FDF20_RS04395	891521..891925	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FDF20_RS04400	892024..892704	+	681	WP_000721572.1	hypothetical protein	-
FDF20_RS04405	892706..892969	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	865456..904587	39131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T124842 WP_000838146.1 NZ_CP040050:891246-891428 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T124842 NZ_CP040050:891246-891428 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT124842 WP_000966688.1 NZ_CP040050:891521-891925 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT124842 NZ_CP040050:891521-891925 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6