Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1014685..1015336 Replicon chromosome
Accession NZ_CP039993
Organism Acinetobacter baumannii strain TG22182

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag EA674_RS04915 Protein ID WP_000838146.1
Coordinates 1014685..1014867 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag EA674_RS04920 Protein ID WP_000966689.1
Coordinates 1014932..1015336 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EA674_RS04865 1009941..1010606 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
EA674_RS04870 1010611..1011000 + 390 WP_000008492.1 hypothetical protein -
EA674_RS04875 1011002..1011370 + 369 WP_000524231.1 hypothetical protein -
EA674_RS04880 1011379..1011783 + 405 WP_000248324.1 hypothetical protein -
EA674_RS04885 1011755..1012123 + 369 WP_000539752.1 hypothetical protein -
EA674_RS04890 1012125..1012523 + 399 WP_001132270.1 hypothetical protein -
EA674_RS04895 1012525..1012737 + 213 WP_000121166.1 hypothetical protein -
EA674_RS04900 1012845..1013774 + 930 WP_000094300.1 hypothetical protein -
EA674_RS04905 1013819..1014352 + 534 WP_001185622.1 hypothetical protein -
EA674_RS04915 1014685..1014867 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
EA674_RS04920 1014932..1015336 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EA674_RS04925 1015417..1015818 + 402 WP_000720591.1 hypothetical protein -
EA674_RS04930 1015879..1019844 + 3966 WP_000191304.1 tape measure protein -
EA674_RS04935 1019962..1020303 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 984291..1038907 54616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T124736 WP_000838146.1 NZ_CP039993:1014685-1014867 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T124736 NZ_CP039993:1014685-1014867 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT124736 WP_000966689.1 NZ_CP039993:1014932-1015336 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT124736 NZ_CP039993:1014932-1015336 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References