Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5490338..5490933 Replicon chromosome
Accession NZ_CP039990
Organism Pseudomonas aeruginosa strain T2101

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag FDK04_RS25985 Protein ID WP_003113526.1
Coordinates 5490655..5490933 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FDK04_RS25980 Protein ID WP_003099268.1
Coordinates 5490338..5490643 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDK04_RS25945 5485478..5486326 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
FDK04_RS25955 5486493..5487434 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
FDK04_RS25960 5487551..5488165 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
FDK04_RS25965 5488207..5488791 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
FDK04_RS25970 5488832..5489932 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
FDK04_RS25980 5490338..5490643 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
FDK04_RS25985 5490655..5490933 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDK04_RS25990 5491262..5493490 + 2229 WP_021264080.1 TonB-dependent receptor -
FDK04_RS25995 5493560..5494207 - 648 WP_003095021.1 carbonate dehydratase -
FDK04_RS26000 5494269..5495507 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T124720 WP_003113526.1 NZ_CP039990:c5490933-5490655 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T124720 NZ_CP039990:c5490933-5490655 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGTTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT124720 WP_003099268.1 NZ_CP039990:c5490643-5490338 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT124720 NZ_CP039990:c5490643-5490338 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References