Detailed information of TA system TA124516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 2192018..2192952
• Replicon: chromosome
• Accession: NZ_CP039928
• Organism: Shewanella sp. MEBiC00475

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FCN25_RS09660
• Protein ID: WP_137224162.1
• Coordinates: 2192419..2192952 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FCN25_RS09655
• Protein ID: WP_175405936.1
• Coordinates: 2192018..2192422 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN25_RS09630	2187270..2188040	+	771	WP_137224150.1	DeoR family transcriptional regulator	-
FCN25_RS09635	2188075..2189904	+	1830	WP_137224152.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
FCN25_RS09640	2190309..2190443	-	135	WP_137224154.1	hypothetical protein	-
FCN25_RS09645	2190650..2190988	-	339	WP_137224156.1	cytosolic protein	-
FCN25_RS09650	2191275..2191802	+	528	WP_137224158.1	hypothetical protein	-
FCN25_RS09655	2192018..2192422	+	405	WP_175405936.1	DUF1778 domain-containing protein	Antitoxin
FCN25_RS09660	2192419..2192952	+	534	WP_137224162.1	GNAT family N-acetyltransferase	Toxin
FCN25_RS09665	2193411..2193749	+	339	WP_137224163.1	DUF805 domain-containing protein	-
FCN25_RS09670	2193919..2195112	-	1194	WP_137224165.1	class I SAM-dependent methyltransferase	-
FCN25_RS09675	2195628..2197229	-	1602	WP_137224167.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (50-126)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20276.60 Da
• Isoelectric Point: 9.1188

>T124516 WP_137224162.1 NZ_CP039928:2192419-2192952 [Shewanella sp. MEBiC00475]
VSWGKEFVELSKSYHDRNSFDCGEQELNTFIKTQAAKHMEAGISRTMILPSAQPLLNQKFAICAFYSVAPSSINRETLPE
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDPAQAFYTKFGFEVLCEHNG
RIRMFLPMKTIERLFNQ

Nucleotide

• Length: 534 bp

>T124516 NZ_CP039928:2192419-2192952 [Shewanella sp. MEBiC00475]
GTGAGTTGGGGTAAAGAGTTCGTAGAACTTAGTAAATCATATCACGACCGCAACTCATTCGACTGTGGTGAGCAAGAGCT
AAATACATTTATCAAAACTCAAGCAGCAAAGCATATGGAAGCAGGTATTAGTCGAACAATGATTCTCCCTAGTGCTCAGC
CATTGCTTAATCAGAAGTTTGCAATATGTGCATTTTACAGTGTTGCGCCTAGCTCAATCAATCGAGAAACCTTACCAGAG
CAACTAGCAAAGAAACTTCCTCGATACCCAATTCCAGTGTTTCTTTTAGCTCAGTTAGCTGTGCATAAGGAATTTCACGG
CTCTGGGCTAGGAAAAGTCAGTTTAATCCGTGCTCTGAAGTACCTTTGGGAAGTTAACCACCATATGAGGGCTTATGCTA
TTGTCGTGGACTGTCTCACTGATCCAGCACAGGCATTCTATACAAAATTTGGCTTTGAAGTATTGTGTGAACATAATGGA
CGCATTCGCATGTTTCTACCAATGAAAACGATAGAAAGACTTTTTAACCAATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14775.07 Da
• Isoelectric Point: 4.9056

>AT124516 WP_175405936.1 NZ_CP039928:2192018-2192422 [Shewanella sp. MEBiC00475]
INASQCRIEIITLFIIRNLSVQVECVQCLNYNLCRYGICPYTGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVV
RLMDEDATNVIENHEGIVVQDSVFDAFMAACNKAKSPNQALLNAAKFTDESGIK

Nucleotide

• Length: 405 bp

>AT124516 NZ_CP039928:2192018-2192422 [Shewanella sp. MEBiC00475]
ATTAATGCATCTCAGTGTCGTATCGAGATTATTACGCTTTTTATAATCCGTAATCTTTCCGTACAAGTTGAATGTGTTCA
ATGTTTGAACTATAATCTCTGTCGTTACGGAATATGTCCGTACACTGGAGGAGTTATGGCAACAGCACGTTTAGATATCC
GTCTTGATGAAGAGATAAAAGCGAAAGCAGAAAAGGCATCAGCATTGCTTGGTCTGAAAAGTTTAACTGAATATGTAGTT
AGGCTTATGGACGAAGATGCAACAAACGTAATTGAGAACCACGAAGGTATCGTGGTTCAAGATAGTGTCTTTGACGCATT
TATGGCTGCTTGTAACAAAGCAAAATCGCCAAATCAAGCTTTGTTGAATGCTGCAAAATTCACAGATGAGAGCGGTATCA
AGTGA