Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3116963..3117650 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FBY8
Locus tag FCU26_RS15415 Protein ID WP_011799298.1
Coordinates 3117207..3117650 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag FCU26_RS15410 Protein ID WP_003414620.1
Coordinates 3116963..3117220 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU26_RS15390 3112283..3113137 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FCU26_RS15395 3113193..3114356 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FCU26_RS15400 3114373..3115587 - 1215 WP_011799297.1 zinc metalloprotease Rip -
FCU26_RS15405 3115595..3116836 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FCU26_RS15410 3116963..3117220 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
FCU26_RS15415 3117207..3117650 + 444 WP_011799298.1 type II toxin-antitoxin system VapC family toxin Toxin
FCU26_RS15420 3117730..3118392 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
FCU26_RS15425 3118488..3118679 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FCU26_RS15430 3119011..3120759 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
FCU26_RS15435 3120855..3121436 + 582 WP_003414644.1 fasciclin domain-containing protein -
FCU26_RS15440 3121536..3121802 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16625.74 Da        Isoelectric Point: 6.4890

>T124432 WP_011799298.1 NZ_CP039850:3117207-3117650 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDTLLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T124432 NZ_CP039850:3117207-3117650 [Mycobacterium tuberculosis variant bovis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACACCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT124432 WP_003414620.1 NZ_CP039850:3116963-3117220 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT124432 NZ_CP039850:3116963-3117220 [Mycobacterium tuberculosis variant bovis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBY8

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References