Detailed information of TA system TA124213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3066310..3066818
• Replicon: chromosome
• Accession: NZ_CP039700
• Organism: Vibrio cyclitrophicus strain ECSMB14105

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FAZ90_RS13875
• Protein ID: WP_046209478.1
• Coordinates: 3066310..3066570 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FAZ90_RS13880
• Protein ID: WP_046209479.1
• Coordinates: 3066567..3066818 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ90_RS13860	3061923..3062966	-	1044	WP_046209476.1	alkene reductase	-
FAZ90_RS13865	3063259..3063948	-	690	WP_046209477.1	hypothetical protein	-
FAZ90_RS13870	3063969..3065570	-	1602	WP_052714397.1	hypothetical protein	-
FAZ90_RS13875	3066310..3066570	-	261	WP_046209478.1	Txe/YoeB family addiction module toxin	Toxin
FAZ90_RS13880	3066567..3066818	-	252	WP_046209479.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FAZ90_RS13885	3067449..3068492	-	1044	WP_046209480.1	alkene reductase	-
FAZ90_RS13890	3068815..3069639	-	825	WP_046209481.1	hypothetical protein	-
FAZ90_RS13895	3069645..3070115	-	471	WP_046209482.1	hypothetical protein	-
FAZ90_RS13900	3070116..3070766	-	651	WP_016797272.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	htpB / ugd / wbtL	3039977..3113344	73367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10205.67 Da
• Isoelectric Point: 9.4087

>T124213 WP_046209478.1 NZ_CP039700:c3066570-3066310 [Vibrio cyclitrophicus]
MSRMLAWTDEALNDYLYWQGQDKKTLKRINKLITDAKRSPFEGIGKPEPLKENLTGFWSRRIDDTNRLVYAINDSHLTII
ACRYHY

Nucleotide

• Length: 261 bp

>T124213 NZ_CP039700:c3066570-3066310 [Vibrio cyclitrophicus]
ATGAGTCGAATGTTAGCTTGGACTGATGAAGCGTTGAATGACTATTTATATTGGCAAGGGCAGGACAAGAAAACCCTTAA
ACGTATTAATAAGTTAATTACAGATGCAAAGCGATCACCATTTGAAGGCATTGGCAAACCTGAACCATTGAAAGAGAACT
TAACAGGTTTCTGGTCTCGCAGGATTGACGATACAAATAGACTCGTTTATGCCATTAATGATTCACATTTAACGATAATT
GCTTGTCGTTATCATTACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9234.30 Da
• Isoelectric Point: 4.3707

>AT124213 WP_046209479.1 NZ_CP039700:c3066818-3066567 [Vibrio cyclitrophicus]
MRIVSFTEARNGLKSVLDGVVNDADCTVITRRDSEDAVVMSMDYYNSLMETVYLSRSPANAAHLNKSIAEYNAGQTTERD
LLE

Nucleotide

• Length: 252 bp

>AT124213 NZ_CP039700:c3066818-3066567 [Vibrio cyclitrophicus]
ATGCGTATAGTTTCTTTTACTGAAGCCAGAAATGGTCTTAAATCTGTTCTTGATGGCGTGGTTAATGATGCAGATTGCAC
AGTTATCACTCGTCGAGATTCTGAAGACGCGGTTGTAATGTCTATGGACTATTACAACAGTTTAATGGAAACGGTATATT
TATCACGTTCTCCTGCGAATGCTGCTCATTTAAACAAATCAATTGCTGAATACAATGCAGGTCAAACCACGGAAAGAGAT
TTGCTTGAATGA