Detailed information of TA system TA124163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 60585..61110
• Replicon: plasmid PNCS014857 strain 14[5]12:i:-
• Accession: NZ_CP039580
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014857

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: E5N99_RS24675
• Protein ID: WP_001159863.1
• Coordinates: 60585..60890 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: E5N99_RS24680
• Protein ID: WP_000813641.1
• Coordinates: 60892..61110 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5N99_RS24635	55964..56524	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
E5N99_RS25225	56680..56967	+	288	WP_071530243.1	hypothetical protein	-
E5N99_RS24640	57244..57729	-	486	WP_000905606.1	membrane protein	-
E5N99_RS24645	57723..58232	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
E5N99_RS24655	58236..58949	-	714	Protein_63	EAL domain-containing protein	-
E5N99_RS24660	58958..59740	-	783	WP_000082169.1	site-specific integrase	-
E5N99_RS24665	59775..60296	-	522	WP_000198608.1	hypothetical protein	-
E5N99_RS24670	60293..60583	-	291	WP_001266176.1	hypothetical protein	-
E5N99_RS24675	60585..60890	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
E5N99_RS24680	60892..61110	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E5N99_RS24685	61786..62307	+	522	WP_010999942.1	hypothetical protein	-
E5N99_RS24695	62791..63087	+	297	WP_001687482.1	hypothetical protein	-
E5N99_RS24700	63581..64570	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
E5N99_RS24710	64929..65633	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..125502	125502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T124163 WP_001159863.1 NZ_CP039580:c60890-60585 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T124163 NZ_CP039580:c60890-60585 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT124163 WP_000813641.1 NZ_CP039580:c61110-60892 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT124163 NZ_CP039580:c61110-60892 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6