Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 3123520..3123916 Replicon chromosome
Accession NZ_CP039548
Organism Enterococcus faecalis strain VE18379

Toxin (Protein)


Gene name txpA Uniprot ID Q82Z30
Locus tag FAJ42_RS16515 Protein ID WP_002387585.1
Coordinates 3123773..3123916 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 3123520..3123662 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAJ42_RS16505 3119032..3119229 + 198 WP_002372618.1 putative holin-like toxin -
FAJ42_RS16510 3119419..3123177 - 3759 WP_010706868.1 WxL domain-containing protein -
- 3123520..3123662 - 143 - - Antitoxin
FAJ42_RS16515 3123773..3123916 + 144 WP_002387585.1 putative holin-like toxin Toxin
FAJ42_RS17110 3124106..3127165 - 3060 WP_002387586.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5244.37 Da        Isoelectric Point: 10.5719

>T124124 WP_002387585.1 NZ_CP039548:3123773-3123916 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Download         Length: 144 bp

>T124124 NZ_CP039548:3123773-3123916 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin


Download         Length: 143 bp

>AT124124 NZ_CP039548:c3123662-3123520 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059MXV6

Antitoxin

Download structure file

References