Detailed information of TA system TA124068

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1527636..1528315
• Replicon: chromosome
• Accession: NZ_CP039518
• Organism: Acinetobacter baumannii strain TG22653

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EA719_RS07255
• Protein ID: WP_000838146.1
• Coordinates: 1527636..1527818 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EA719_RS07260
• Protein ID: WP_000966688.1
• Coordinates: 1527911..1528315 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EA719_RS07210	1522709..1523113	+	405	WP_000247948.1	hypothetical protein	-
EA719_RS07215	1523085..1523453	+	369	WP_002055488.1	hypothetical protein	-
EA719_RS07220	1523455..1523853	+	399	WP_001251850.1	hypothetical protein	-
EA719_RS07225	1523855..1524073	+	219	WP_001277687.1	hypothetical protein	-
EA719_RS07230	1524167..1524520	+	354	WP_000064599.1	hypothetical protein	-
EA719_RS07235	1524520..1525755	+	1236	WP_000002422.1	hypothetical protein	-
EA719_RS07240	1525808..1526725	+	918	WP_000094250.1	hypothetical protein	-
EA719_RS07245	1526795..1527310	+	516	WP_001185608.1	hypothetical protein	-
EA719_RS07255	1527636..1527818	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EA719_RS07260	1527911..1528315	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EA719_RS07265	1528414..1528590	+	177	WP_014466185.1	hypothetical protein	-
EA719_RS07270	1528599..1528922	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
EA719_RS07275	1528954..1529748	+	795	WP_000720608.1	hypothetical protein	-
EA719_RS07280	1529797..1530036	-	240	WP_000763623.1	Arc family DNA-binding protein	-
EA719_RS07285	1530159..1530314	+	156	WP_001103649.1	Arc family DNA-binding protein	-
EA719_RS07290	1530311..1531303	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1512478..1554417	41939

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T124068 WP_000838146.1 NZ_CP039518:1527636-1527818 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T124068 NZ_CP039518:1527636-1527818 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT124068 WP_000966688.1 NZ_CP039518:1527911-1528315 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT124068 NZ_CP039518:1527911-1528315 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6