Detailed information of TA system TA123672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 26109..26722
• Replicon: plasmid unnamed3
• Accession: NZ_CP039207
• Organism: Piscirickettsia salmonis strain Psal-182

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Psal182_RS17640
• Protein ID: WP_155085027.1
• Coordinates: 26399..26722 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Psal182_RS17635
• Protein ID: WP_155085026.1
• Coordinates: 26109..26402 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psal182_RS17615	21700..22239	+	540	WP_155085022.1	hypothetical protein	-
Psal182_RS17620	22229..22510	+	282	WP_155085023.1	hypothetical protein	-
Psal182_RS17625	22686..23294	+	609	WP_155085024.1	hypothetical protein	-
Psal182_RS17630	23667..26099	+	2433	WP_155085025.1	hypothetical protein	-
Psal182_RS17635	26109..26402	-	294	WP_155085026.1	helix-turn-helix domain-containing protein	Antitoxin
Psal182_RS17640	26399..26722	-	324	WP_155085027.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Psal182_RS17645	27013..27351	-	339	WP_155085028.1	hypothetical protein	-
Psal182_RS17650	27356..27703	-	348	WP_155085029.1	hypothetical protein	-
Psal182_RS17655	28106..28543	-	438	WP_155085030.1	hypothetical protein	-
Psal182_RS17660	29071..29325	-	255	WP_155085031.1	hypothetical protein	-
Psal182_RS17665	29322..29498	-	177	WP_155085032.1	hypothetical protein	-
Psal182_RS17670	29767..31641	-	1875	WP_155085033.1	RecX family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..44615	44615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-90)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12242.54 Da
• Isoelectric Point: 10.6012

>T123672 WP_155085027.1 NZ_CP039207:c26722-26399 [Piscirickettsia salmonis]
MAWKISYFNGKVMEQVLAWPKGVLANYLHISELMQEFGPNLGLPHTKAMGDGLFEIRAKGQEGIGRAFFCTVVKNEVIIL
HSIIKKTQKTPDKDLKLARKRLKEFKR

Nucleotide

• Length: 324 bp

>T123672 NZ_CP039207:c26722-26399 [Piscirickettsia salmonis]
ATGGCTTGGAAAATCAGTTACTTTAATGGCAAAGTAATGGAACAAGTCTTAGCGTGGCCCAAAGGCGTACTTGCAAACTA
CCTGCACATCAGTGAATTAATGCAAGAATTTGGCCCTAACTTAGGTTTACCTCACACCAAAGCAATGGGTGATGGTTTAT
TTGAGATTCGAGCCAAAGGCCAAGAAGGAATTGGTAGAGCGTTTTTTTGTACTGTGGTTAAAAATGAAGTCATTATCCTT
CATTCCATTATCAAAAAAACACAGAAAACGCCAGATAAAGATTTAAAGCTTGCTCGTAAGCGCTTGAAGGAGTTTAAACG
ATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11048.70 Da
• Isoelectric Point: 9.8352

>AT123672 WP_155085026.1 NZ_CP039207:c26402-26109 [Piscirickettsia salmonis]
MSKRPTHDEFLKKALTKPGVQAIYDDLDEEYQLIRELLLARKQANKSQEEVAQEMHTTRSAISRLESHGKNSPSISTLRK
YAEAVGCKLQIRLIPAK

Nucleotide

• Length: 294 bp

>AT123672 NZ_CP039207:c26402-26109 [Piscirickettsia salmonis]
ATGAGTAAACGACCCACTCATGATGAATTTTTGAAAAAAGCACTGACTAAACCAGGTGTTCAAGCTATCTATGATGATTT
AGATGAAGAATACCAGCTTATTCGAGAATTACTCCTTGCTCGCAAACAGGCAAATAAATCTCAAGAAGAAGTCGCTCAAG
AAATGCATACCACGCGCAGTGCAATTTCTAGACTGGAATCTCATGGTAAAAACTCTCCCTCTATCAGTACGTTGCGTAAA
TATGCTGAAGCAGTAGGGTGTAAACTACAGATCAGATTAATTCCAGCAAAATAA