Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2401261..2402030 Replicon chromosome
Accession NZ_CP038856
Organism Citrobacter freundii strain Upstream_1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag E5284_RS11350 Protein ID WP_135912047.1
Coordinates 2401548..2402030 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag E5284_RS11345 Protein ID WP_168246960.1
Coordinates 2401261..2401557 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5284_RS11330 2396761..2397948 + 1188 WP_135912045.1 outer membrane protein transport protein -
E5284_RS11335 2398228..2398857 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
E5284_RS11340 2399166..2401148 + 1983 WP_135912869.1 MBL fold metallo-hydrolase -
E5284_RS11345 2401261..2401557 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
E5284_RS11350 2401548..2402030 + 483 WP_135912047.1 GNAT family N-acetyltransferase Toxin
E5284_RS11355 2402131..2402895 - 765 WP_135912048.1 SDR family oxidoreductase -
E5284_RS11360 2403044..2403937 + 894 WP_135912049.1 LysR family transcriptional regulator -
E5284_RS11365 2403972..2404250 - 279 Protein_2204 aldo/keto reductase -
E5284_RS11370 2404708..2405757 + 1050 WP_135912050.1 NAD(P)-dependent alcohol dehydrogenase -
E5284_RS23170 2405850..2406005 + 156 WP_161959027.1 hypothetical protein -
E5284_RS11375 2406030..2406821 + 792 WP_135912051.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17755.36 Da        Isoelectric Point: 7.8926

>T123251 WP_135912047.1 NZ_CP038856:2401548-2402030 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T123251 NZ_CP038856:2401548-2402030 [Citrobacter freundii]
ATGGAAATAAACGTCACGGCGCCGGCGTTGCTGACCGAAGGGCATGAGCTGCAGCCATTCGATTGCGGTAATGAGGTGTT
AAATGATTGGCTACGTCGCCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTGGAGTCTA
CTCAGCGCGTAGTGGGTTACTATTCCATTGCAACTGGATCCGTGAGCCACGCTGACTTAGGGCGTAGCTTACGTCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTCTGTTGGGCCGTCTTGCTGTTGATGCCAGTACGCAAGGTCATAGTTATGGAAAATG
GCTGCTTAATGATGCTGTACTGCGCATTTCCAACTTAGCCGATCAAGTGGGTATCAAAGCCATCATGGTACATGCTATTG
ATGGTAAGGCCAGAGCGTTCTATGAATATTTCGGTTTCGTTCAGTCCCCAATAGCGGCAAATACGTTGTTCTACAAAATT
TAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT123251 WP_168246960.1 NZ_CP038856:2401261-2401557 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT123251 NZ_CP038856:2401261-2401557 [Citrobacter freundii]
ATGGAGAAACTTATGCAAACCAGCGCTCGTAAGCCAACTCGCGATAAGCAAATTAATATCCGCGCTACTGATGAGGAACG
CGCAGTGATTGATTATGCCGCAAGTTTGGTTAATAAAAACCGCACTGACTTTATCATTGAGAAGGCCGTGCATGAGGCCC
AGAATATCATTCTGGATCAGCGTGTGTTCGTCCTGGACGATGCCCGATATCAGTCTTTCATTGAGCAGCTTGAAGCGCCT
GTACAAAATGTTGAGGGGCGTCAACGCCTGATGGATGTGAAGCCAGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References