Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 422395..422933 Replicon chromosome
Accession NZ_CP038819
Organism Staphylococcus aureus strain O82

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag SaO82_RS02010 Protein ID WP_136142518.1
Coordinates 422607..422933 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag SaO82_RS02005 Protein ID WP_001058493.1
Coordinates 422395..422604 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO82_RS01955 417445..417636 - 192 WP_001052483.1 hypothetical protein -
SaO82_RS01965 417880..418176 + 297 WP_001261460.1 30S ribosomal protein S6 -
SaO82_RS01970 418197..418700 + 504 WP_000934799.1 single-stranded DNA-binding protein -
SaO82_RS01975 418752..418994 + 243 WP_000897044.1 30S ribosomal protein S18 -
SaO82_RS01980 419235..420464 - 1230 WP_136142516.1 site-specific integrase -
SaO82_RS01985 420920..421615 - 696 WP_000668212.1 helix-turn-helix domain-containing protein -
SaO82_RS01990 421759..421971 + 213 WP_136142517.1 helix-turn-helix transcriptional regulator -
SaO82_RS01995 421972..422244 + 273 WP_000091734.1 helix-turn-helix domain-containing protein -
SaO82_RS02000 422256..422402 + 147 WP_031824147.1 hypothetical protein -
SaO82_RS02005 422395..422604 + 210 WP_001058493.1 hypothetical protein Antitoxin
SaO82_RS02010 422607..422933 + 327 WP_136142518.1 DUF1474 family protein Toxin
SaO82_RS02015 422998..423867 + 870 WP_001002726.1 primase alpha helix C-terminal domain-containing protein -
SaO82_RS02020 423881..425590 + 1710 WP_000447458.1 DUF927 domain-containing protein -
SaO82_RS02025 425902..426282 + 381 WP_000356937.1 hypothetical protein -
SaO82_RS02030 426279..426920 + 642 WP_001019787.1 hypothetical protein -
SaO82_RS02035 427267..427608 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 418197..436396 18199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13032.46 Da        Isoelectric Point: 4.7171

>T123218 WP_136142518.1 NZ_CP038819:422607-422933 [Staphylococcus aureus]
MNWEIKSLFSDLELLKDSFKDLKDNHGWHFDKLYPHEPNHVLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFCEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T123218 NZ_CP038819:422607-422933 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAAGTTTATTTAGCGATTTAGAGTTGTTGAAAGATAGTTTTAAGGATTTAAAGGATAATCATGG
TTGGCATTTTGATAAGTTATATCCTCATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTGTGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8152.19 Da        Isoelectric Point: 4.4665

>AT123218 WP_001058493.1 NZ_CP038819:422395-422604 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEVSREKHLELIMKWCAQELKNNFQLGKGE

Download         Length: 210 bp

>AT123218 NZ_CP038819:422395-422604 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTCGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References