123192

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2430032..2430567 Replicon chromosome
Accession NZ_CP038807
Organism Staphylococcus lugdunensis strain APC 3758

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag E5Z44_RS11540 Protein ID WP_002445368.1
Coordinates 2430032..2430355 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag E5Z44_RS11545 Protein ID WP_001058489.1
Coordinates 2430358..2430567 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Z44_RS11510 2425129..2425362 - 234 WP_002492317.1 hypothetical protein -
E5Z44_RS11515 2425376..2425720 - 345 WP_002445374.1 hypothetical protein -
E5Z44_RS11520 2426008..2426649 - 642 WP_002492310.1 pathogenicity island protein -
E5Z44_RS11525 2426663..2427028 - 366 WP_002445372.1 hypothetical protein -
E5Z44_RS11530 2427376..2429085 - 1710 WP_002445371.1 DUF927 domain-containing protein -
E5Z44_RS11535 2429099..2429968 - 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
E5Z44_RS11540 2430032..2430355 - 324 WP_002445368.1 DUF1474 family protein Toxin
E5Z44_RS11545 2430358..2430567 - 210 WP_001058489.1 hypothetical protein Antitoxin
E5Z44_RS11550 2430560..2430706 - 147 WP_002445365.1 hypothetical protein -
E5Z44_RS11555 2430703..2431020 - 318 WP_002445364.1 helix-turn-helix domain-containing protein -
E5Z44_RS11560 2431025..2431243 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
E5Z44_RS11565 2431416..2432090 + 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
E5Z44_RS11570 2432104..2433276 + 1173 WP_002492309.1 site-specific integrase -
E5Z44_RS11575 2433345..2434966 - 1622 Protein_2237 chaperonin GroEL -
E5Z44_RS11580 2435025..2435309 - 285 WP_002461410.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2422140..2435309 13169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T123192 WP_002445368.1 NZ_CP038807:c2430355-2430032 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T123192 NZ_CP038807:c2430355-2430032 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT123192 WP_001058489.1 NZ_CP038807:c2430567-2430358 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT123192 NZ_CP038807:c2430567-2430358 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References