Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1079542..1080068 Replicon chromosome
Accession NZ_CP038499
Organism Dickeya dianthicola strain LAR.16.03.LID

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4CNM8
Locus tag E4659_RS05045 Protein ID WP_024104817.1
Coordinates 1079542..1079847 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CA80
Locus tag E4659_RS05050 Protein ID WP_024104818.1
Coordinates 1079850..1080068 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4659_RS05020 (E4659_05110) 1074586..1075605 + 1020 WP_024108335.1 NADP-dependent oxidoreductase -
E4659_RS05025 (E4659_05115) 1075806..1076808 + 1003 Protein_981 IS110 family transposase -
E4659_RS05030 (E4659_05120) 1077117..1077320 + 204 Protein_982 transposase -
E4659_RS05035 (E4659_05125) 1077310..1077945 - 636 Protein_983 IS256 family transposase -
E4659_RS05040 (E4659_05130) 1078254..1079258 - 1005 WP_024108039.1 IS110 family transposase -
E4659_RS05045 (E4659_05135) 1079542..1079847 - 306 WP_024104817.1 type II toxin-antitoxin system toxin CcdB Toxin
E4659_RS05050 (E4659_05140) 1079850..1080068 - 219 WP_024104818.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
E4659_RS05055 (E4659_05145) 1080127..1080453 - 327 Protein_987 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
E4659_RS05060 (E4659_05150) 1080681..1080863 - 183 WP_024109619.1 hypothetical protein -
E4659_RS05065 (E4659_05155) 1081012..1081728 - 717 WP_024104820.1 SprT family zinc-dependent metalloprotease -
E4659_RS05070 (E4659_05160) 1081728..1084823 - 3096 WP_024108175.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1065449..1169789 104340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11820.63 Da        Isoelectric Point: 4.6983

>T122998 WP_024104817.1 NZ_CP038499:c1079847-1079542 [Dickeya dianthicola]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T122998 NZ_CP038499:c1079847-1079542 [Dickeya dianthicola]
ATGCAATTCATTGTTTACCAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCAAAGCGGCGTATGGTCATTCCGCTTATAGAATCGCATCACCTGTCTGAGAAGGTGAATAAAACGCTGTTCCCTCAGA
TCCGGATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTTCCCGTTGAAGTTATTGGTGAAGAGCTC
GCGGAGCTTGGCGACTATGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8191.17 Da        Isoelectric Point: 8.6383

>AT122998 WP_024104818.1 NZ_CP038499:c1080068-1079850 [Dickeya dianthicola]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT122998 NZ_CP038499:c1080068-1079850 [Dickeya dianthicola]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAACTATCAGATTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGCAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCTGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CNM8

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CA80

References