Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4679029..4679863 | Replicon | chromosome |
| Accession | NZ_CP038394 | ||
| Organism | Escherichia coli O157:H7 strain DEC5A | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | E3155_RS22765 | Protein ID | WP_000854819.1 |
| Coordinates | 4679029..4679406 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | F4THW5 |
| Locus tag | E3155_RS22770 | Protein ID | WP_001313071.1 |
| Coordinates | 4679495..4679863 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3155_RS22730 | 4675180..4675422 | + | 243 | Protein_4452 | N-acetylneuraminic acid mutarotase | - |
| E3155_RS22735 | 4675496..4676347 | + | 852 | WP_000168588.1 | HNH endonuclease | - |
| E3155_RS22740 | 4676545..4676732 | - | 188 | Protein_4454 | transposase | - |
| E3155_RS22745 | 4676807..4677634 | - | 828 | WP_001359437.1 | integrase arm-type DNA-binding domain-containing protein | - |
| E3155_RS22750 | 4678098..4678250 | - | 153 | WP_001280446.1 | hypothetical protein | - |
| E3155_RS22755 | 4678335..4678532 | - | 198 | WP_000839278.1 | DUF957 domain-containing protein | - |
| E3155_RS22760 | 4678544..4679032 | - | 489 | WP_000761721.1 | hypothetical protein | - |
| E3155_RS22765 | 4679029..4679406 | - | 378 | WP_000854819.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| E3155_RS22770 | 4679495..4679863 | - | 369 | WP_001313071.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| E3155_RS22775 | 4679943..4680164 | - | 222 | WP_000692301.1 | DUF987 domain-containing protein | - |
| E3155_RS22780 | 4680227..4680703 | - | 477 | WP_001186726.1 | RadC family protein | - |
| E3155_RS22785 | 4680719..4681204 | - | 486 | WP_000849584.1 | antirestriction protein | - |
| E3155_RS22790 | 4681259..4682077 | - | 819 | WP_001234649.1 | DUF945 domain-containing protein | - |
| E3155_RS22795 | 4682177..4682410 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| E3155_RS22800 | 4682489..4682944 | - | 456 | WP_000581504.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4671482..4714452 | 42970 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14160.18 Da Isoelectric Point: 7.8523
>T122343 WP_000854819.1 NZ_CP038394:c4679406-4679029 [Escherichia coli O157:H7]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T122343 NZ_CP038394:c4679406-4679029 [Escherichia coli O157:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13498.23 Da Isoelectric Point: 5.8696
>AT122343 WP_001313071.1 NZ_CP038394:c4679863-4679495 [Escherichia coli O157:H7]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT122343 NZ_CP038394:c4679863-4679495 [Escherichia coli O157:H7]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|