Detailed information of TA system TA120904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 825290..825822
• Replicon: chromosome
• Accession: NZ_CP038269
• Organism: Staphylococcus aureus strain O331 isolate B114

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SaO331_RS04100
• Protein ID: WP_001103942.1
• Coordinates: 825502..825822 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SaO331_RS04095
• Protein ID: WP_001058486.1
• Coordinates: 825290..825499 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO331_RS04050	820309..821529	-	1221	WP_000266157.1	site-specific integrase	-
SaO331_RS04055	821618..822346	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
SaO331_RS04060	822370..823098	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
SaO331_RS04065	823168..823599	-	432	WP_001228759.1	hypothetical protein	-
SaO331_RS04070	823616..824074	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SaO331_RS04075	824086..824418	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SaO331_RS04080	824611..824874	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SaO331_RS04085	824867..825139	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SaO331_RS04090	825151..825297	+	147	WP_000784875.1	hypothetical protein	-
SaO331_RS04095	825290..825499	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SaO331_RS04100	825502..825822	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SaO331_RS04105	825886..826755	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
SaO331_RS04110	826772..828241	+	1470	WP_000390454.1	virulence-associated E family protein	-
SaO331_RS04120	828527..828889	+	363	WP_001039168.1	hypothetical protein	-
SaO331_RS04125	828891..829175	+	285	WP_000998181.1	hypothetical protein	-
SaO331_RS04130	829172..829813	+	642	WP_001019764.1	hypothetical protein	-
SaO331_RS04135	830330..830671	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	802279..835622	33343

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T120904 WP_001103942.1 NZ_CP038269:825502-825822 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T120904 NZ_CP038269:825502-825822 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT120904 WP_001058486.1 NZ_CP038269:825290-825499 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT120904 NZ_CP038269:825290-825499 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4