Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 8726..9297 Replicon plasmid pEH_mcr4.3
Accession NZ_CP038261
Organism Acinetobacter baumannii strain 39741

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag E4K02_RS19440 Protein ID WP_011638897.1
Coordinates 8986..9297 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag E4K02_RS19435 Protein ID WP_011638898.1
Coordinates 8726..8986 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K02_RS19405 4066..4302 + 237 WP_114237987.1 hypothetical protein -
E4K02_RS19410 4407..4697 - 291 WP_034121062.1 hypothetical protein -
E4K02_RS19415 4916..5119 - 204 WP_034121061.1 hypothetical protein -
E4K02_RS19420 5316..5966 - 651 WP_052201470.1 HNH endonuclease -
E4K02_RS19425 6168..7793 - 1626 WP_011638903.1 phosphoethanolamine--lipid A transferase MCR-4.3 -
E4K02_RS19430 7967..8556 - 590 Protein_9 recombinase family protein -
E4K02_RS19435 8726..8986 + 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4K02_RS19440 8986..9297 + 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K02_RS19445 9321..12407 + 3087 WP_123794410.1 Tn3 family transposase -
E4K02_RS19450 12449..12712 - 264 WP_034121059.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..18786 18786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T120881 WP_011638897.1 NZ_CP038261:8986-9297 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T120881 NZ_CP038261:8986-9297 [Acinetobacter baumannii]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT120881 WP_011638898.1 NZ_CP038261:8726-8986 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT120881 NZ_CP038261:8726-8986 [Acinetobacter baumannii]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References