Detailed information of TA system TA120856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 960608..961860
• Replicon: chromosome
• Accession: NZ_CP038251
• Organism: Streptococcus pneumoniae strain TVO_1901944

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J2GTV6
• Locus tag: ES300_RS04870
• Protein ID: WP_000405373.1
• Coordinates: 961084..961860 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: ES300_RS04865
• Protein ID: WP_000579602.1
• Coordinates: 960608..961084 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES300_RS04845 (ES300_05100)	955681..956535	+	855	WP_000900021.1	ADP-ribosylglycohydrolase family protein	-
ES300_RS04850 (ES300_05105)	956647..957531	+	885	WP_000710113.1	diacylglycerol kinase family lipid kinase	-
ES300_RS04855 (ES300_05110)	957694..959433	+	1740	Protein_970	glycoside hydrolase family 13 protein	-
ES300_RS04860 (ES300_05115)	959708..960163	+	456	WP_000500478.1	hypothetical protein	-
ES300_RS04865 (ES300_05120)	960608..961084	+	477	WP_000579602.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
ES300_RS04870 (ES300_05125)	961084..961860	+	777	WP_000405373.1	type II toxin-antitoxin system toxin PezT	Toxin
ES300_RS04875 (ES300_05130)	961844..962653	+	810	WP_000413878.1	SAVED domain-containing protein	-
ES300_RS04880 (ES300_05135)	962650..965733	+	3084	WP_000569044.1	DEAD/DEAH box helicase	-
ES300_RS04885 (ES300_05140)	965758..966654	+	897	WP_000161642.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	943412..966654	23242

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29509.43 Da
• Isoelectric Point: 6.9224

>T120856 WP_000405373.1 NZ_CP038251:961084-961860 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQSIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
ENGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNPARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KVGEERMRDMSKSNGKDA

Nucleotide

• Length: 777 bp

>T120856 NZ_CP038251:961084-961860 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAATCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAAAATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTATTAAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACCAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTATGCTATCAATCCAAATCCAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAACGGATGAGGGATATGAGTAAAAGTAATGGAAAAGATGCATAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT120856 WP_000579602.1 NZ_CP038251:960608-961084 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT120856 NZ_CP038251:960608-961084 [Streptococcus pneumoniae]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J2GTV6