Detailed information of TA system TA120721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1334343..1334998
• Replicon: chromosome
• Accession: NZ_CP038141
• Organism: Swingsia samuiensis strain AH83

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E3D00_RS06190
• Protein ID: WP_141460909.1
• Coordinates: 1334567..1334998 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E3D00_RS06185
• Protein ID: WP_141460907.1
• Coordinates: 1334343..1334567 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3D00_RS06145	1329570..1329815	+	246	WP_141462401.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
E3D00_RS06150	1329812..1330198	+	387	WP_141460897.1	type II toxin-antitoxin system VapC family toxin	-
E3D00_RS06155	1330272..1330505	-	234	Protein_1179	DDE-type integrase/transposase/recombinase	-
E3D00_RS06160	1330682..1331035	-	354	WP_141460899.1	hypothetical protein	-
E3D00_RS06165	1331061..1332371	-	1311	WP_141460901.1	PAAR domain-containing protein	-
E3D00_RS06170	1332375..1332845	-	471	WP_141460903.1	DcrB-related protein	-
E3D00_RS06175	1332995..1333573	-	579	WP_141462402.1	site-specific integrase	-
E3D00_RS06180	1333687..1333953	-	267	WP_141460905.1	WGR domain-containing protein	-
E3D00_RS06185	1334343..1334567	+	225	WP_141460907.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E3D00_RS06190	1334567..1334998	+	432	WP_141460909.1	type II toxin-antitoxin system VapC family toxin	Toxin
E3D00_RS06195	1335830..1336519	+	690	Protein_1187	IS6 family transposase	-
E3D00_RS06200	1336745..1337557	+	813	WP_141460911.1	aminoglycoside phosphotransferase family protein	-
E3D00_RS06205	1337664..1338074	+	411	WP_181441940.1	tyrosine-type recombinase/integrase	-
E3D00_RS06215	1338499..1339617	-	1119	WP_141460915.1	Mrp/NBP35 family ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16311.75 Da
• Isoelectric Point: 8.2682

>T120721 WP_141460909.1 NZ_CP038141:1334567-1334998 [Swingsia samuiensis]
MLRYALDTNFCIRVLRDRPQALRERFNENADALCISDVVLYELLYGAEKSQDPVKHRRQVELFAARLTILPFDDAAAAHT
AEIRAVLENKGCVIGPYDLMIAGHARSRGLIVVTGNLREFTRVDGLRSEDWLPKYGPWRSKPQ

Nucleotide

• Length: 432 bp

>T120721 NZ_CP038141:1334567-1334998 [Swingsia samuiensis]
ATGCTCCGCTACGCACTCGACACGAATTTCTGTATTCGGGTATTGCGCGATCGACCTCAGGCCTTGAGAGAACGCTTTAA
CGAGAATGCGGATGCGCTCTGCATTTCTGATGTTGTCTTGTATGAACTCCTCTACGGTGCAGAAAAATCTCAGGATCCGG
TAAAACATCGACGACAAGTCGAGCTTTTTGCTGCACGCTTAACGATCTTGCCCTTTGATGATGCCGCAGCTGCCCATACG
GCAGAAATCCGGGCTGTTTTAGAAAACAAAGGCTGCGTCATAGGTCCTTATGATCTTATGATAGCTGGACATGCTCGCAG
CCGGGGCCTCATCGTCGTAACTGGAAACCTTCGTGAATTTACGAGAGTAGACGGTCTTCGTTCCGAAGACTGGCTGCCAA
AATATGGCCCTTGGAGGAGCAAACCTCAATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8286.46 Da
• Isoelectric Point: 5.0001

>AT120721 WP_141460907.1 NZ_CP038141:1334343-1334567 [Swingsia samuiensis]
MLTRTTLFLSNRSQAVRLPKAVSFASELKEVVIIPDGARRIIAPADAAWDDFFTSPGIELAPRNQPEIQERESF

Nucleotide

• Length: 225 bp

>AT120721 NZ_CP038141:1334343-1334567 [Swingsia samuiensis]
ATGCTGACCCGCACGACACTCTTCTTGTCGAACCGTTCTCAAGCGGTGCGTCTTCCTAAAGCTGTTTCTTTTGCGTCCGA
GCTAAAGGAGGTGGTCATCATTCCCGATGGTGCACGCCGGATCATTGCGCCAGCCGATGCAGCTTGGGATGACTTCTTTA
CGTCACCCGGTATTGAACTAGCCCCCCGCAATCAGCCCGAAATACAGGAGCGTGAAAGCTTTTGA