Detailed information of TA system TA120677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 109479..110032
• Replicon: chromosome
• Accession: NZ_CP038030
• Organism: Rhodococcus ruber strain R1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E2561_RS00485
• Protein ID: WP_059175309.1
• Coordinates: 109751..110032 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E2561_RS00480
• Protein ID: WP_140188148.1
• Coordinates: 109479..109754 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2561_RS00460	105662..105949	+	288	Protein_90	hypothetical protein	-
E2561_RS00465	106120..107505	-	1386	WP_140188145.1	site-specific recombinase	-
E2561_RS00470	107603..107935	-	333	WP_140188146.1	helix-turn-helix transcriptional regulator	-
E2561_RS00475	107932..109077	-	1146	WP_140188147.1	site-specific integrase	-
E2561_RS00480	109479..109754	+	276	WP_140188148.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E2561_RS00485	109751..110032	+	282	WP_059175309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2561_RS00490	110420..110725	+	306	Protein_96	transposase	-
E2561_RS00495	111016..112068	-	1053	WP_140188149.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
E2561_RS00500	112065..114203	-	2139	WP_140189088.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (37-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10498.03 Da
• Isoelectric Point: 10.2269

>T120677 WP_059175309.1 NZ_CP038030:109751-110032 [Rhodococcus ruber]
MTEEAPAPYGVAIASPARRALSRLPGRIVHAVVEFISGPLADNPHRLSKPLRNDLEGLRSARRGDYRILLRVDDDHRTIL
IVDIDHRAHIYRT

Nucleotide

• Length: 282 bp

>T120677 NZ_CP038030:109751-110032 [Rhodococcus ruber]
ATGACCGAGGAGGCGCCGGCACCCTACGGCGTCGCGATCGCCTCACCGGCCCGCCGGGCCCTGTCCCGACTACCGGGGCG
GATCGTGCATGCGGTCGTCGAGTTCATCTCCGGCCCACTCGCAGACAATCCCCACCGGCTGAGCAAGCCGCTGCGGAACG
ATCTCGAGGGCCTGCGCAGTGCCCGTCGCGGCGACTACCGCATCCTGCTGCGCGTCGACGACGACCACCGCACCATCCTG
ATCGTCGACATCGACCACCGCGCCCACATCTACCGAACCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9792.03 Da
• Isoelectric Point: 4.8210

>AT120677 WP_140188148.1 NZ_CP038030:109479-109754 [Rhodococcus ruber]
MTTVPLGEAKDKLSALVDSAEATHDIITITRHGKPAAVLMSADDLESLHETIYWLSRPGTAEAVAIADREYAAGRTVSLD
ELRAEHGLPPR

Nucleotide

• Length: 276 bp

>AT120677 NZ_CP038030:109479-109754 [Rhodococcus ruber]
ATGACGACGGTACCGCTCGGCGAAGCGAAGGACAAGCTCTCGGCGCTGGTGGACAGTGCCGAAGCCACGCACGACATCAT
CACGATCACCCGGCACGGCAAACCGGCCGCGGTCCTGATGTCGGCCGACGATCTGGAATCACTACACGAGACGATCTACT
GGCTGTCTCGGCCCGGGACCGCCGAGGCGGTCGCGATCGCCGACCGCGAGTACGCCGCCGGCCGGACCGTCTCGCTCGAC
GAGCTGCGCGCCGAGCACGGCCTGCCGCCCCGATGA