Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1291543..1292100 Replicon chromosome
Accession NZ_CP038017
Organism Allofrancisella frigidaquae strain SYSU 10HL1970

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3E15_RS06090 Protein ID WP_209451694.1
Coordinates 1291855..1292100 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag E3E15_RS06085 Protein ID WP_035719955.1
Coordinates 1291543..1291833 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3E15_RS06060 1287564..1287830 + 267 Protein_1172 transposase -
E3E15_RS06065 1287993..1289042 + 1050 WP_172106981.1 hypothetical protein -
E3E15_RS06070 1289249..1290116 + 868 Protein_1174 IS5 family transposase -
E3E15_RS06075 1290233..1290490 - 258 WP_172106982.1 hypothetical protein -
E3E15_RS06080 1290487..1291158 - 672 WP_172106983.1 hypothetical protein -
E3E15_RS06085 1291543..1291833 - 291 WP_035719955.1 HigA family addiction module antidote protein Antitoxin
E3E15_RS06090 1291855..1292100 - 246 WP_209451694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3E15_RS06095 1292619..1293542 + 924 WP_172106984.1 cysteine synthase family protein -
E3E15_RS06100 1293639..1293797 + 159 WP_172106985.1 hypothetical protein -
E3E15_RS06105 1293808..1294380 + 573 WP_035720005.1 disulfide bond formation protein B -
E3E15_RS06110 1294463..1295452 - 990 WP_172106986.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1289625..1290116 491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9580.06 Da        Isoelectric Point: 9.9177

>T120649 WP_209451694.1 NZ_CP038017:c1292100-1291855 [Allofrancisella frigidaquae]
ISSKHARKVPNTIYKVAIRKLDMLNAAKVIEDLRIPPNNRLEQLKGNLKEYHSIRINDQYRVIFKCQDNEAYDVDIVNYH
K

Download         Length: 246 bp

>T120649 NZ_CP038017:c1292100-1291855 [Allofrancisella frigidaquae]
ATATCAAGTAAACATGCTAGAAAAGTACCAAACACTATATACAAAGTAGCTATAAGAAAACTGGATATGCTAAATGCTGC
TAAAGTAATTGAGGATTTGAGAATTCCTCCAAACAATAGGCTAGAGCAGTTAAAAGGAAATTTGAAAGAGTATCACTCAA
TAAGGATTAATGATCAGTATCGTGTGATATTCAAGTGTCAAGATAATGAAGCATATGATGTTGATATAGTTAACTATCAT
AAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10823.42 Da        Isoelectric Point: 7.4669

>AT120649 WP_035719955.1 NZ_CP038017:c1291833-1291543 [Allofrancisella frigidaquae]
MFIPANRQPTHPGEVLLHEFIEPLGITQKKLAEHLGWTYARLNEIVNGKRGVTADSALSLSETFGVTPDFWLNLQIAYDL
YSAKRTHKHVKPLDVA

Download         Length: 291 bp

>AT120649 NZ_CP038017:c1291833-1291543 [Allofrancisella frigidaquae]
ATGTTTATACCAGCAAATAGACAACCAACACATCCAGGAGAGGTGTTGTTACATGAGTTTATAGAACCATTAGGTATTAC
TCAAAAAAAGCTAGCAGAACACTTAGGCTGGACCTATGCTAGATTAAATGAGATTGTTAATGGTAAAAGAGGAGTAACTG
CAGACAGTGCTTTATCTCTGAGTGAAACATTTGGAGTTACCCCAGATTTTTGGTTAAACCTTCAAATAGCTTATGATCTA
TATTCTGCTAAACGAACACATAAACATGTAAAGCCGCTTGATGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References