Detailed information of TA system TA120635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5540125..5540761
• Replicon: chromosome
• Accession: NZ_CP038001
• Organism: Pseudomonas sp. SXM-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DCC84_RS26075
• Protein ID: WP_008432929.1
• Coordinates: 5540125..5540529 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7Y8FB80
• Locus tag: DCC84_RS26080
• Protein ID: WP_008432930.1
• Coordinates: 5540522..5540761 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCC84_RS26055	5536013..5537329	+	1317	WP_134327175.1	hypothetical protein	-
DCC84_RS26060	5537717..5538867	+	1151	WP_134326149.1	IS3 family transposase	-
DCC84_RS26070	5539442..5540083	+	642	WP_087693117.1	HAD-IB family hydrolase	-
DCC84_RS26075	5540125..5540529	-	405	WP_008432929.1	type II toxin-antitoxin system VapC family toxin	Toxin
DCC84_RS26080	5540522..5540761	-	240	WP_008432930.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DCC84_RS26085	5541046..5542005	-	960	WP_102369727.1	LysR family transcriptional regulator	-
DCC84_RS26090	5542268..5543695	+	1428	WP_134327176.1	argininosuccinate lyase	-
DCC84_RS26095	5543834..5544712	+	879	WP_003211504.1	amino acid ABC transporter permease	-
DCC84_RS26100	5544736..5545500	+	765	WP_003211502.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5534145..5552672	18527

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15157.49 Da
• Isoelectric Point: 7.4665

>T120635 WP_008432929.1 NZ_CP038001:c5540529-5540125 [Pseudomonas sp. SXM-1]
MIKYMLDTNIVIYIIKRRPMEILEKFNANVGRMVISSITLAELMHGAEKSQFVERNTRAVEDFISRLDVIHYDDKAAFHY
GSIRSDLEKKGTPIGVNDLHIAGHARSSGLVLVTNNEGEFKRVNGLIVENWIAA

Nucleotide

• Length: 405 bp

>T120635 NZ_CP038001:c5540529-5540125 [Pseudomonas sp. SXM-1]
ATGATTAAGTACATGCTTGATACGAACATCGTGATCTACATCATCAAGCGTCGGCCTATGGAAATACTGGAAAAATTCAA
TGCGAATGTAGGTCGTATGGTGATCTCTTCGATCACCCTTGCGGAACTGATGCACGGGGCCGAAAAAAGCCAGTTTGTTG
AGAGAAATACTCGGGCGGTGGAGGACTTCATCTCCCGGCTTGACGTCATTCACTACGATGACAAGGCCGCTTTTCACTAC
GGCTCGATCCGCTCCGATCTCGAAAAGAAGGGCACTCCAATCGGCGTAAATGACCTGCACATCGCGGGCCACGCCAGAAG
CTCAGGATTGGTCTTGGTGACTAACAACGAAGGTGAGTTCAAGCGAGTGAATGGCTTGATCGTGGAAAACTGGATCGCCG
CCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9031.93 Da
• Isoelectric Point: 4.0941

>AT120635 WP_008432930.1 NZ_CP038001:c5540761-5540522 [Pseudomonas sp. SXM-1]
MSTGTIFTNNRTQNIRIPADMRFPAGVKTVEVRAVGRELIISPVENTWDSFFLASESVSDDFMEERADQTQQERESFDD

Nucleotide

• Length: 240 bp

>AT120635 NZ_CP038001:c5540761-5540522 [Pseudomonas sp. SXM-1]
ATGTCTACTGGAACGATCTTCACCAATAACCGTACACAAAATATCCGCATCCCTGCTGATATGCGTTTTCCCGCTGGGGT
GAAAACTGTAGAGGTGCGTGCCGTGGGGCGCGAACTGATTATTTCGCCGGTTGAAAACACTTGGGACAGCTTTTTCCTTG
CAAGCGAATCGGTATCTGATGATTTTATGGAGGAGCGCGCCGACCAAACCCAGCAAGAGCGAGAGTCCTTTGATGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8FB80