Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3693002..3693224 Replicon chromosome
Accession NZ_CP037857
Organism Escherichia coli BW25113 strain AM187

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag E1A98_RS18045 Protein ID WP_000141634.1
Coordinates 3693002..3693109 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3693158..3693224 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1A98_RS18020 3688255..3689007 - 753 Protein_3509 cellulose biosynthesis protein BcsQ -
E1A98_RS18025 3689019..3689207 - 189 WP_001063318.1 YhjR family protein -
E1A98_RS18030 3689480..3691051 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
E1A98_RS18035 3691048..3691239 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
E1A98_RS18040 3691236..3692915 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
E1A98_RS18045 3693002..3693109 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3693158..3693224 + 67 - - Antitoxin
E1A98_RS18050 3693585..3694856 + 1272 WP_001295225.1 transporter -
E1A98_RS18055 3694886..3695890 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
E1A98_RS18060 3695887..3696870 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
E1A98_RS18065 3696881..3697783 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T120231 WP_000141634.1 NZ_CP037857:c3693109-3693002 [Escherichia coli BW25113]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T120231 NZ_CP037857:c3693109-3693002 [Escherichia coli BW25113]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT120231 NZ_CP037857:3693158-3693224 [Escherichia coli BW25113]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References