Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2814083..2814292 Replicon chromosome
Accession NZ_CP037835
Organism Clostridioides difficile strain Cd7

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H30_RS13250 Protein ID WP_004454815.1
Coordinates 2814134..2814292 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2814083..2814217 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H30_RS13235 (2809111) 2809111..2810739 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H30_RS13240 (2810860) 2810860..2811855 + 996 WP_003431031.1 asparaginase -
E1H30_RS19945 (2812044) 2812044..2812292 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2814083) 2814083..2814217 + 135 NuclAT_1 - Antitoxin
- (2814083) 2814083..2814217 + 135 NuclAT_1 - Antitoxin
- (2814083) 2814083..2814217 + 135 NuclAT_2 - Antitoxin
E1H30_RS13250 (2814134) 2814134..2814292 - 159 WP_004454815.1 hypothetical protein Toxin
E1H30_RS13255 (2814651) 2814651..2816021 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H30_RS19955 (2816457) 2816457..2816543 + 87 WP_231298880.1 hypothetical protein -
E1H30_RS19960 (2816587) 2816587..2816886 - 300 WP_225722727.1 hypothetical protein -
E1H30_RS13270 (2817073) 2817073..2817345 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H30_RS13275 (2817663) 2817663..2818331 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120164 WP_004454815.1 NZ_CP037835:c2814292-2814134 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120164 NZ_CP037835:c2814292-2814134 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120164 NZ_CP037835:2814083-2814217 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References