Detailed information of TA system TA120157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1742400..1742614
• Replicon: chromosome
• Accession: NZ_CP037835
• Organism: Clostridioides difficile strain Cd7

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: -
• Locus tag: E1H30_RS08305
• Protein ID: WP_032508407.1
• Coordinates: 1742400..1742561 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1742481..1742614 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1H30_RS08270 (1737588)	1737588..1737878	+	291	WP_021358995.1	HK97 gp10 family phage protein	-
E1H30_RS08275 (1737988)	1737988..1738794	+	807	WP_021358994.1	hypothetical protein	-
E1H30_RS20060 (1739143)	1739143..1739268	+	126	WP_021358993.1	hypothetical protein	-
E1H30_RS08280 (1739247)	1739247..1739579	+	333	WP_021358992.1	hypothetical protein	-
E1H30_RS08285 (1739572)	1739572..1739748	+	177	WP_021358991.1	hypothetical protein	-
E1H30_RS08290 (1739750)	1739750..1741060	+	1311	WP_021358990.1	phage tail sheath family protein	-
E1H30_RS08295 (1741077)	1741077..1741547	+	471	WP_003429851.1	phage tail tube protein	-
E1H30_RS08300 (1741619)	1741619..1742059	+	441	WP_003429853.1	phage portal protein	-
E1H30_RS08305 (1742400)	1742400..1742561	+	162	WP_032508407.1	hypothetical protein	Toxin
- (1742481)	1742481..1742614	-	134	NuclAT_2	-	Antitoxin
- (1742481)	1742481..1742614	-	134	NuclAT_2	-	Antitoxin
- (1742481)	1742481..1742614	-	134	NuclAT_3	-	Antitoxin
- (1742481)	1742481..1742614	-	134	NuclAT_4	-	Antitoxin
- (1742959)	1742959..1743007	-	49	NuclAT_10	-	-
- (1742959)	1742959..1743007	-	49	NuclAT_6	-	-
- (1742959)	1742959..1743007	-	49	NuclAT_6	-	-
- (1742959)	1742959..1743007	-	49	NuclAT_8	-	-
- (1743986)	1743986..1744091	-	106	NuclAT_5	-	-
- (1743986)	1743986..1744091	-	106	NuclAT_5	-	-
- (1743986)	1743986..1744091	-	106	NuclAT_7	-	-
- (1743986)	1743986..1744091	-	106	NuclAT_9	-	-
E1H30_RS19890 (1744557)	1744557..1744694	+	138	WP_021359009.1	hypothetical protein	-
E1H30_RS08315 (1744942)	1744942..1745502	+	561	WP_021359010.1	phage lipoprotein	-
E1H30_RS08320 (1745545)	1745545..1746114	+	570	WP_021359011.1	zinc ribbon domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T120157 WP_032508407.1 NZ_CP037835:1742400-1742561 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCIICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T120157 NZ_CP037835:1742400-1742561 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCATAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT120157 NZ_CP037835:c1742614-1742481 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Antitoxin