Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1531462..1531658 Replicon chromosome
Accession NZ_CP037822
Organism Clostridioides difficile strain Cd11

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag E1H34_RS07155 Protein ID WP_009902496.1
Coordinates 1531462..1531614 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1531558..1531658 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H34_RS07135 (1527002) 1527002..1527550 - 549 WP_011861206.1 DUF308 domain-containing protein -
E1H34_RS07140 (1527702) 1527702..1528130 + 429 WP_021369464.1 DMT family transporter -
E1H34_RS07145 (1528197) 1528197..1528865 + 669 WP_003429358.1 diphthine--ammonia ligase -
E1H34_RS07150 (1528983) 1528983..1530338 - 1356 WP_021370295.1 MATE family efflux transporter -
E1H34_RS07155 (1531462) 1531462..1531614 + 153 WP_009902496.1 hypothetical protein Toxin
- (1531558) 1531558..1531658 - 101 NuclAT_3 - Antitoxin
- (1531558) 1531558..1531658 - 101 NuclAT_3 - Antitoxin
- (1531558) 1531558..1531658 - 101 NuclAT_3 - Antitoxin
E1H34_RS07160 (1532709) 1532709..1534442 - 1734 WP_021363452.1 sensor domain-containing diguanylate cyclase -
E1H34_RS07165 (1534682) 1534682..1535527 - 846 WP_021363453.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T120103 WP_009902496.1 NZ_CP037822:1531462-1531614 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T120103 NZ_CP037822:1531462-1531614 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT120103 NZ_CP037822:c1531658-1531558 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References