Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2895425..2895634 Replicon chromosome
Accession NZ_CP037818
Organism Clostridioides difficile strain Cd14

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H37_RS13890 Protein ID WP_004454815.1
Coordinates 2895476..2895634 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2895425..2895559 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H37_RS13875 (2891052) 2891052..2892680 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H37_RS13880 (2892801) 2892801..2893796 + 996 WP_003431031.1 asparaginase -
E1H37_RS19805 (2893985) 2893985..2894233 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2895425) 2895425..2895559 + 135 NuclAT_1 - Antitoxin
- (2895425) 2895425..2895559 + 135 NuclAT_1 - Antitoxin
- (2895425) 2895425..2895559 + 135 NuclAT_2 - Antitoxin
E1H37_RS13890 (2895476) 2895476..2895634 - 159 WP_004454815.1 hypothetical protein Toxin
E1H37_RS13895 (2895993) 2895993..2897363 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H37_RS19815 (2897799) 2897799..2897885 + 87 WP_231298880.1 hypothetical protein -
E1H37_RS13910 (2898415) 2898415..2898687 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H37_RS13915 (2899005) 2899005..2899673 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120091 WP_004454815.1 NZ_CP037818:c2895634-2895476 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120091 NZ_CP037818:c2895634-2895476 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120091 NZ_CP037818:2895425-2895559 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References