Detailed information of TA system TA119925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4275611..4276206
• Replicon: chromosome
• Accession: NZ_CP036514
• Organism: Hafnia alvei strain PCM_1220

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A377P9M7
• Locus tag: EYZ02_RS19790
• Protein ID: WP_046360051.1
• Coordinates: 4275937..4276206 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EYZ02_RS19785
• Protein ID: WP_046360052.1
• Coordinates: 4275611..4275940 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYZ02_RS19775	4270877..4271416	-	540	WP_043489601.1	type 1 fimbrial protein	-
EYZ02_RS19780	4272840..4275548	+	2709	WP_046360053.1	magnesium-translocating P-type ATPase	-
EYZ02_RS19785	4275611..4275940	-	330	WP_046360052.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EYZ02_RS19790	4275937..4276206	-	270	WP_046360051.1	type II toxin-antitoxin system HicA family toxin	Toxin
EYZ02_RS19795	4276511..4277086	+	576	WP_046360050.1	nuclear transport factor 2 family protein	-
EYZ02_RS19800	4277128..4278325	-	1198	Protein_3823	NAD(P)/FAD-dependent oxidoreductase	-
EYZ02_RS19805	4278649..4280142	+	1494	WP_025799474.1	inorganic phosphate transporter PitA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (28-76)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10123.97 Da
• Isoelectric Point: 10.9768

>T119925 WP_046360051.1 NZ_CP036514:c4276206-4275937 [Hafnia alvei]
MSTHKLSARHQRTLYVIFTNPPIRTLEWRKIENLLIALGAVVSEGQGSRVKFEIGGVVVLLHRPHPRKEAKIYQITELRA
FLEVVGVIP

Nucleotide

• Length: 270 bp

>T119925 NZ_CP036514:c4276206-4275937 [Hafnia alvei]
ATGTCGACTCATAAGCTCAGTGCCAGACACCAACGAACGCTATACGTTATTTTCACTAACCCGCCGATACGAACGCTAGA
GTGGCGGAAGATTGAAAACTTGTTAATCGCCCTCGGTGCCGTGGTTTCTGAAGGTCAAGGCTCACGCGTTAAATTTGAAA
TTGGTGGCGTTGTTGTATTGCTCCACCGTCCGCATCCTAGGAAGGAGGCGAAGATCTATCAAATAACAGAATTGAGAGCC
TTTCTTGAAGTGGTGGGAGTGATTCCATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12216.74 Da
• Isoelectric Point: 5.6365

>AT119925 WP_046360052.1 NZ_CP036514:c4275940-4275611 [Hafnia alvei]
MNEMTYKGYTARIEYSHEDNCLVGRLAGIRDLISFHADNVADLRKEFEISVDDYLEYCASRGREPQRPASGKISLRVPPD
VHSQINVAAEVAGKSVNQWITDTLIKACS

Nucleotide

• Length: 330 bp

>AT119925 NZ_CP036514:c4275940-4275611 [Hafnia alvei]
ATGAATGAAATGACTTATAAAGGCTATACCGCACGTATTGAATATAGCCATGAAGACAATTGCTTAGTTGGCCGTTTGGC
TGGTATTCGCGACTTAATTAGCTTTCACGCCGACAACGTGGCTGATTTGCGTAAAGAGTTTGAGATTTCTGTGGATGACT
ATCTGGAATATTGTGCTTCACGAGGGCGTGAACCCCAGCGTCCCGCGAGCGGCAAAATTAGCCTGCGTGTACCGCCAGAT
GTGCACTCACAGATCAATGTGGCGGCAGAGGTTGCGGGTAAAAGTGTGAACCAGTGGATCACTGATACATTAATTAAAGC
CTGTTCTTAA

Structures

Toxin

• AlphaFold DB: A0A377P9M7