Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 2309785..2310579 Replicon chromosome
Accession NZ_CP036514
Organism Hafnia alvei strain PCM_1220

Toxin (Protein)


Gene name ataT Uniprot ID A0A097R2E8
Locus tag EYZ02_RS10930 Protein ID WP_025801386.1
Coordinates 2310058..2310579 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A097R2F1
Locus tag EYZ02_RS10925 Protein ID WP_025801385.1
Coordinates 2309785..2310054 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYZ02_RS10910 2305381..2306412 - 1032 WP_040044923.1 Mal regulon transcriptional regulator MalI -
EYZ02_RS10915 2306663..2308258 + 1596 WP_025801383.1 maltose/glucose-specific PTS transporter subunit IIBC -
EYZ02_RS10920 2308342..2309517 + 1176 WP_131391289.1 pyridoxal phosphate-dependent aminotransferase -
EYZ02_RS10925 2309785..2310054 + 270 WP_025801385.1 DUF1778 domain-containing protein Antitoxin
EYZ02_RS10930 2310058..2310579 + 522 WP_025801386.1 GNAT family N-acetyltransferase Toxin
EYZ02_RS10935 2310777..2311775 + 999 WP_046359972.1 adenosine deaminase -
EYZ02_RS10940 2312371..2313366 - 996 WP_131391291.1 bile acid:sodium symporter -
EYZ02_RS10945 2313528..2314571 - 1044 WP_131391293.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-152)

Antitoxin

Vibrio phage ICP1, Orf50

(3-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19396.20 Da        Isoelectric Point: 6.9676

>T119913 WP_025801386.1 NZ_CP036514:2310058-2310579 [Hafnia alvei]
MPDLTIAIFSSEAEYDFSDFDCGEESLNVFLTDHLARQHNARILRGYLLITQTPKPKVVGYYTLSGSCFEKETLPSNTQK
RKVPYVNVPSITLGRLAIQKDLHGQEWGTALVTHAMQVVYRASLAVGVHGMFVDALNEKAKQFYLKLGFIALTGNNANSL
FYPTKSIEKLFED

Download         Length: 522 bp

>T119913 NZ_CP036514:2310058-2310579 [Hafnia alvei]
ATGCCTGACTTAACCATTGCGATTTTTTCGAGTGAGGCTGAATACGATTTCTCCGACTTTGACTGCGGCGAAGAATCCCT
GAATGTATTCCTTACCGATCATTTGGCCCGCCAGCATAATGCGCGAATTTTACGTGGCTATTTACTCATAACCCAAACGC
CAAAACCCAAAGTCGTTGGTTATTACACGCTATCTGGTAGCTGCTTCGAAAAGGAAACGCTGCCGTCAAATACCCAGAAA
CGCAAAGTGCCTTATGTCAACGTACCCAGTATCACTTTAGGGCGTCTCGCCATTCAAAAAGATCTCCATGGACAAGAATG
GGGAACGGCGCTGGTGACTCACGCGATGCAAGTGGTCTATCGAGCATCGCTCGCCGTGGGCGTTCACGGTATGTTTGTCG
ATGCACTCAATGAGAAAGCAAAGCAGTTCTACCTGAAGCTTGGATTTATCGCTCTCACAGGCAATAACGCAAACTCGCTT
TTCTACCCAACCAAATCCATCGAAAAGCTGTTCGAGGATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10097.51 Da        Isoelectric Point: 5.8580

>AT119913 WP_025801385.1 NZ_CP036514:2309785-2310054 [Hafnia alvei]
MSALKKQRIDLRLTDEDKNAIEEAAAMSNQTITQFMLTSASERAAEVIEQHRRLILSDESWNLVMDAISTPPAPNDRLKR
AAKRLQSME

Download         Length: 270 bp

>AT119913 NZ_CP036514:2309785-2310054 [Hafnia alvei]
ATGTCTGCATTAAAAAAACAGCGTATCGATCTTCGATTAACTGACGAAGACAAAAACGCCATTGAAGAAGCTGCGGCGAT
GTCCAACCAAACTATCACGCAGTTTATGCTTACCAGCGCCTCTGAACGAGCTGCGGAAGTTATCGAGCAACACCGTCGCT
TGATCCTCAGCGATGAGTCATGGAATCTGGTAATGGATGCCATCAGCACCCCACCGGCACCGAACGATAGACTTAAACGC
GCAGCCAAACGTCTGCAAAGTATGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097R2E8

Antitoxin

Source ID Structure
AlphaFold DB A0A097R2F1

References