Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 435038..435819 Replicon chromosome
Accession NZ_CP036514
Organism Hafnia alvei strain PCM_1220

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag EYZ02_RS01980 Protein ID WP_131390507.1
Coordinates 435328..435819 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag EYZ02_RS01975 Protein ID WP_131390506.1
Coordinates 435038..435331 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYZ02_RS01955 430886..431794 - 909 WP_131390502.1 LysR family transcriptional regulator -
EYZ02_RS01960 431917..433335 + 1419 WP_131390503.1 aldehyde dehydrogenase family protein -
EYZ02_RS01965 433398..433901 - 504 WP_131390504.1 phenolic acid decarboxylase -
EYZ02_RS01970 434005..434898 + 894 WP_131390505.1 LysR family transcriptional regulator -
EYZ02_RS01975 435038..435331 + 294 WP_131390506.1 DUF1778 domain-containing protein Antitoxin
EYZ02_RS01980 435328..435819 + 492 WP_131390507.1 GNAT family N-acetyltransferase Toxin
EYZ02_RS01985 436090..437232 + 1143 WP_131390508.1 Fic family protein -
EYZ02_RS01990 437351..438541 + 1191 WP_131390509.1 hypothetical protein -
EYZ02_RS01995 438947..439406 + 460 Protein_372 hypothetical protein -
EYZ02_RS02000 439403..439628 + 226 Protein_373 helix-turn-helix domain-containing protein -
EYZ02_RS02005 440029..440781 - 753 WP_046458235.1 KilA-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17888.86 Da        Isoelectric Point: 8.5162

>T119907 WP_131390507.1 NZ_CP036514:435328-435819 [Hafnia alvei]
MISAPEPLHTKHDVNAFCCGVDSMDNWLRRRAMKNQLTGASRTFVCCDDNARVMAYYSLASSAVMSNSAPGRFRRNMPDP
IPVVVLGRLAIDKSLHSKGIGRALVRDAGLRVIHVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
GSV

Download         Length: 492 bp

>T119907 NZ_CP036514:435328-435819 [Hafnia alvei]
ATGATCTCCGCTCCTGAACCACTTCACACCAAACACGATGTTAATGCATTTTGCTGTGGTGTGGATTCTATGGATAACTG
GCTCAGGCGGCGGGCGATGAAAAATCAGCTAACCGGAGCATCTCGTACCTTTGTGTGCTGCGATGATAATGCCAGAGTTA
TGGCGTATTACTCATTAGCGTCCAGCGCGGTGATGAGCAACTCTGCCCCCGGCCGCTTTCGCCGTAACATGCCAGACCCG
ATCCCTGTCGTGGTGTTAGGACGACTGGCGATAGATAAATCACTGCACAGCAAGGGCATTGGCCGTGCGTTAGTGCGTGA
TGCGGGGTTACGTGTGATTCATGTGGCGGAAACTATTGGCATTCGTGGCATGTTGGTTCACGCACTATCTGATGAAGCGC
GGGAATTTTATCTGCGTGTGGGATTTGAGCCATCGCCAATGGATCCGATGATGCTGATGGTGACGCTGGGGGATTTAGTG
GGGAGTGTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10931.61 Da        Isoelectric Point: 10.1968

>AT119907 WP_131390506.1 NZ_CP036514:435038-435331 [Hafnia alvei]
MPITNSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPDAYQAFLTRLDEAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT119907 NZ_CP036514:435038-435331 [Hafnia alvei]
ATGCCAATAACAAATAGCATGTCGATTAAACGCGAAACATTGAACCTTCGCATTAAACCCGCTGAACGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGAAAAAATCGCACTGATTTTGTTCTGGAAGCTGCACGGGCGGCGGCTGAGGAAGCGTTGA
TCGAACAGCGCATTATCATGGCCGATCCTGATGCTTATCAGGCGTTTTTGACTCGTCTGGATGAAGCTCCTGCACCAAAC
GCCGCACTGCGTAAAACAATGCAAACTCCCGCGCCGTGGGAGCAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References