Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1482617..1483277 Replicon chromosome
Accession NZ_CP036199
Organism Leclercia adecarboxylata strain 16005813

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag EXN74_RS07135 Protein ID WP_032613858.1
Coordinates 1482864..1483277 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag EXN74_RS07130 Protein ID WP_032613860.1
Coordinates 1482617..1482883 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN74_RS07105 1477736..1479169 - 1434 WP_130588237.1 6-phospho-beta-glucosidase BglA -
EXN74_RS07110 1479282..1480013 - 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
EXN74_RS07115 1480066..1480377 + 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
EXN74_RS07120 1480543..1481202 + 660 WP_032613865.1 hemolysin III family protein -
EXN74_RS07125 1481332..1482312 - 981 WP_130588238.1 tRNA-modifying protein YgfZ -
EXN74_RS07130 1482617..1482883 + 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
EXN74_RS07135 1482864..1483277 + 414 WP_032613858.1 protein YgfX Toxin
EXN74_RS07140 1483282..1483803 - 522 WP_117386687.1 flavodoxin FldB -
EXN74_RS07145 1483905..1484801 + 897 WP_130588239.1 site-specific tyrosine recombinase XerD -
EXN74_RS07150 1484827..1485540 + 714 WP_130588240.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EXN74_RS07155 1485546..1487279 + 1734 WP_130588241.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T119330 WP_032613858.1 NZ_CP036199:1482864-1483277 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T119330 NZ_CP036199:1482864-1483277 [Leclercia adecarboxylata]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCGTGGCGCGCCCAGTGGATGTCTCTTTTGCTCCACGGCCTGGTTGCGGC
TTGCATCCTGTTGATACCATGGCCGCTAAGCTACACCCCGTTATGGTTAATTTTACTGTCGCTGGTGGTGTTTGACAGCG
TACGCAGCCAACGGCGCATCAATTCCCGCCAGGGCGAAATCAAGCTATTCATGGATTCCCGCCTGCAGTGGCAGGGTAGC
GAGTGGGAGATTATCGGTACGCCGTGGATGCTCAATTCCGGCATGATGCTCCGCTTACGCAAGGGCGACGGGAAACGCTA
CCAGCATTTGTGGTTGTCGGCAGACAGCATGGATGAAGGGGAGTGGCGGGATCTGCGCCGGATGCTTTCGCAGCAACCGA
CGCACGGGCGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT119330 WP_032613860.1 NZ_CP036199:1482617-1482883 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT119330 NZ_CP036199:1482617-1482883 [Leclercia adecarboxylata]
ATGGACATTACTAACAAAGCCCGCATTCATTGGGCATGCCGTCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
CTTCGAATACGAATACGACACCCTGAGCGATGAGGATAAAAAGCTGTTTATCCGCCTGCTGGAGAACGACGATCCTGATT
TATTTAACTGGTTAATGAATCACGGCGAACCCGCCGACGCCGAACTGCAACGGATGGTGCTTTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References