Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 748142..748734 Replicon chromosome
Accession NZ_CP036175
Organism Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DA718_RS03650 Protein ID WP_112213634.1
Coordinates 748360..748734 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DA718_RS03645 Protein ID WP_112213633.1
Coordinates 748142..748363 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA718_RS03625 743697..744251 + 555 WP_110272946.1 YgjV family protein -
DA718_RS03630 744266..745513 - 1248 WP_112213630.1 serine/threonine transporter SstT -
DA718_RS03635 745767..746735 - 969 WP_112213631.1 TerC family protein -
DA718_RS03640 746992..747981 - 990 WP_112213632.1 Gfo/Idh/MocA family oxidoreductase -
DA718_RS03645 748142..748363 + 222 WP_112213633.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DA718_RS03650 748360..748734 + 375 WP_112213634.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DA718_RS03655 748714..749217 - 504 WP_112213635.1 M48 family metallopeptidase -
DA718_RS03660 749296..750939 - 1644 WP_112213636.1 glycoside hydrolase family 43 protein -
DA718_RS03665 751069..751935 - 867 WP_112213637.1 helix-turn-helix transcriptional regulator -
DA718_RS03670 752168..753511 + 1344 WP_112213638.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13919.01 Da        Isoelectric Point: 6.0798

>T119237 WP_112213634.1 NZ_CP036175:748360-748734 [Klebsiella huaxiensis]
MKWVSASEVIAFHDRILLHLPGIKGMPDPGRAEAIIYRVQNRFHYEGVRDVFELAATYWVAIARGHIFNDGNKRTAFFIT
MAFLARNGYLIADEDTRLEELTVLAATGEATVDVLADALRQLAL

Download         Length: 375 bp

>T119237 NZ_CP036175:748360-748734 [Klebsiella huaxiensis]
ATGAAGTGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGGATTTTACTCCATCTACCTGGTATTAAAGGCATGCC
CGATCCTGGGCGGGCAGAAGCCATTATTTACCGTGTGCAGAACCGTTTTCACTACGAAGGGGTGAGAGACGTTTTTGAAC
TGGCCGCAACTTATTGGGTCGCCATCGCGCGTGGGCATATTTTTAATGATGGTAATAAGAGGACCGCATTTTTTATCACC
ATGGCATTCCTTGCCCGCAATGGATATCTCATCGCTGATGAAGATACCCGGCTGGAAGAACTGACTGTCCTGGCGGCGAC
AGGGGAAGCCACGGTTGATGTGCTGGCCGATGCGCTACGACAGTTGGCGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8155.16 Da        Isoelectric Point: 5.7996

>AT119237 WP_112213633.1 NZ_CP036175:748142-748363 [Klebsiella huaxiensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYEAFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT119237 NZ_CP036175:748142-748363 [Klebsiella huaxiensis]
ATGCGTTCTTATAGTACATCAGAGGCCAGACAGAATATTGCGGCCGTCATGGATGCTGCCGCCAGCGGAGAGCCGATTGA
AATTACCCGGCGTGATGGAACATCTAACGTTTTGATCAGTAAGGCAGAATATGAGGCGTTTATGAATGCCAAATTAGATG
CTGAATTTGATTTTATTATGCAGCGACATGGTCGCACGGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References