Detailed information of TA system TA119205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2458531..2459506
• Replicon: chromosome
• Accession: NZ_CP036101
• Organism: Bacillus wiedmannii strain JAS28/2

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A7V7LCP7
• Locus tag: EXW48_RS12355
• Protein ID: WP_074650800.1
• Coordinates: 2458531..2459268 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EXW48_RS12360
• Protein ID: WP_215563265.1
• Coordinates: 2459381..2459506 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXW48_RS12330 (EXW48_12415)	2453730..2454452	+	723	WP_215563261.1	class I SAM-dependent methyltransferase	-
EXW48_RS12335 (EXW48_12420)	2454560..2454967	+	408	WP_000072477.1	VOC family protein	-
EXW48_RS12340 (EXW48_12425)	2455015..2456691	-	1677	WP_215563262.1	alpha-keto acid decarboxylase family protein	-
EXW48_RS12345 (EXW48_12430)	2456808..2457290	+	483	WP_215563263.1	MarR family transcriptional regulator	-
EXW48_RS12350 (EXW48_12435)	2457457..2458194	+	738	WP_215563264.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
EXW48_RS12355 (EXW48_12440)	2458531..2459268	+	738	WP_074650800.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
EXW48_RS12360 (EXW48_12445)	2459381..2459506	+	126	WP_215563265.1	D-alanyl-D-alanine carboxypeptidase	Antitoxin
EXW48_RS12365	2459582..2459758	+	177	WP_215563266.1	stage II sporulation protein SB	-
EXW48_RS12370 (EXW48_12450)	2459901..2461370	+	1470	WP_215563267.1	beta-Ala-His dipeptidase	-
EXW48_RS12375 (EXW48_12455)	2461966..2462436	-	471	WP_215563268.1	DUF5065 family protein	-
EXW48_RS12380 (EXW48_12460)	2462891..2463550	+	660	WP_215563269.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28385.06 Da
• Isoelectric Point: 8.3034

>T119205 WP_074650800.1 NZ_CP036101:2458531-2459268 [Bacillus wiedmannii]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAMFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T119205 NZ_CP036101:2458531-2459268 [Bacillus wiedmannii]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTCGTTCTTGTGTTCTTTTACTGGAGAAACGA
AGAGTTGTACGAGGAGAAAAAACAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAACCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCATTT
ATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATTGGCAAGACTGTTCAATCGATAAAACGGTC
TTTAATTGCTTCTAAAGCAAGAGGGGAAATATATACAACAATTATTCAAAATGTCAATCCAGCAATGTTCGGTACAATGG
AATGGCATACGGAAGAAGAGTATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACTAACTTTCGCGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAGTTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGCATTATACCAGCAAAAACTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.39 Da
• Isoelectric Point: 4.0338

>AT119205 WP_215563265.1 NZ_CP036101:2459381-2459506 [Bacillus wiedmannii]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLKQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT119205 NZ_CP036101:2459381-2459506 [Bacillus wiedmannii]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTAAAACAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A7V7LCP7