Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2371050..2372028 Replicon chromosome
Accession NZ_CP036046
Organism Bacillus mycoides strain BPN601

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW28_RS12025 Protein ID WP_215584974.1
Coordinates 2371050..2371790 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EXW28_RS12030 Protein ID WP_215552300.1
Coordinates 2371903..2372028 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW28_RS12000 (EXW28_12265) 2367039..2367749 + 711 WP_215552302.1 class I SAM-dependent methyltransferase -
EXW28_RS12005 (EXW28_12270) 2367869..2368282 + 414 WP_215552301.1 VOC family protein -
EXW28_RS12010 (EXW28_12275) 2368459..2369091 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW28_RS12015 (EXW28_12280) 2369365..2369841 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW28_RS12020 (EXW28_12285) 2369995..2370732 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW28_RS12025 (EXW28_12290) 2371050..2371790 + 741 WP_215584974.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW28_RS12030 (EXW28_12295) 2371903..2372028 + 126 WP_215552300.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
EXW28_RS12035 2372104..2372280 + 177 WP_002017052.1 stage II sporulation protein SB -
EXW28_RS12040 (EXW28_12300) 2372300..2372668 - 369 WP_215585107.1 YxeA family protein -
EXW28_RS12045 (EXW28_12305) 2372939..2374408 + 1470 WP_215552299.1 aminoacyl-histidine dipeptidase -
EXW28_RS12050 2374768..2374917 + 150 WP_002069316.1 hypothetical protein -
EXW28_RS12055 (EXW28_12310) 2375673..2376332 + 660 WP_215552298.1 CatB-related O-acetyltransferase -
EXW28_RS29285 2376527..2376675 + 149 Protein_2312 bacitracin ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28495.11 Da        Isoelectric Point: 8.3034

>T119179 WP_215584974.1 NZ_CP036046:2371050-2371790 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKNLNTFLDSYGEKVGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119179 NZ_CP036046:2371050-2371790 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAACTTAAACACATTTTTAGATTCATATGGGGAAAAGGTTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4939.33 Da        Isoelectric Point: 3.8705

>AT119179 WP_215552300.1 NZ_CP036046:2371903-2372028 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLEQVEELEEELKRK

Download         Length: 126 bp

>AT119179 NZ_CP036046:2371903-2372028 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGGAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References