Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 5858..6122 | Replicon | plasmid pTW11681_74 |
| Accession | NZ_CP035859 | ||
| Organism | Escherichia coli TW11681 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | EXE31_RS25525 | Protein ID | WP_001303307.1 |
| Coordinates | 5970..6122 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 5858..5920 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXE31_RS25510 (1959) | 1959..3029 | - | 1071 | WP_000151590.1 | IncI1-type conjugal transfer protein TrbB | - |
| EXE31_RS25515 (3048) | 3048..4256 | - | 1209 | WP_001295719.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (4436) | 4436..4494 | - | 59 | NuclAT_1 | - | - |
| - (4436) | 4436..4494 | - | 59 | NuclAT_1 | - | - |
| - (4436) | 4436..4494 | - | 59 | NuclAT_1 | - | - |
| - (4436) | 4436..4494 | - | 59 | NuclAT_1 | - | - |
| EXE31_RS25520 (4564) | 4564..5649 | - | 1086 | WP_000080544.1 | hypothetical protein | - |
| - (5858) | 5858..5920 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (5858) | 5858..5920 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (5858) | 5858..5920 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (5858) | 5858..5920 | - | 63 | NuclAT_0 | - | Antitoxin |
| EXE31_RS25525 (5970) | 5970..6122 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| EXE31_RS25530 (6194) | 6194..6445 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| EXE31_RS25535 (6745) | 6745..7041 | + | 297 | WP_001275298.1 | DinQ-like type I toxin DqlB | - |
| EXE31_RS25540 (7106) | 7106..7282 | - | 177 | WP_001054898.1 | hypothetical protein | - |
| EXE31_RS25545 (7684) | 7684..7893 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| EXE31_RS25550 (7965) | 7965..8627 | - | 663 | WP_000644795.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| EXE31_RS25555 (8698) | 8698..10866 | - | 2169 | WP_000698356.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..74310 | 74310 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T118847 WP_001303307.1 NZ_CP035859:5970-6122 [Escherichia coli TW11681]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T118847 NZ_CP035859:5970-6122 [Escherichia coli TW11681]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 63 bp
>AT118847 NZ_CP035859:c5920-5858 [Escherichia coli TW11681]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
