Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3437185..3437878 Replicon chromosome
Accession NZ_CP035846
Organism Escherichia coli strain TW10598

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EXA01_RS16695 Protein ID WP_000415584.1
Coordinates 3437185..3437481 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EXA01_RS16700 Protein ID WP_000650107.1
Coordinates 3437483..3437878 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA01_RS16660 (3432273) 3432273..3432587 - 315 WP_000958598.1 putative quinol monooxygenase -
EXA01_RS16665 (3432618) 3432618..3433199 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EXA01_RS16670 (3433518) 3433518..3433850 + 333 WP_000917686.1 DUF2645 family protein -
EXA01_RS16675 (3433896) 3433896..3435245 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
EXA01_RS16680 (3435242) 3435242..3435901 - 660 WP_001221497.1 quorum sensing response regulator transcription factor QseB -
EXA01_RS16685 (3436053) 3436053..3436445 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EXA01_RS16690 (3436498) 3436498..3436980 + 483 WP_000183505.1 GyrI-like domain-containing protein -
EXA01_RS16695 (3437185) 3437185..3437481 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EXA01_RS16700 (3437483) 3437483..3437878 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EXA01_RS16705 (3438011) 3438011..3439618 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EXA01_RS16710 (3439756) 3439756..3442014 + 2259 WP_001281866.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118776 WP_000415584.1 NZ_CP035846:3437185-3437481 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118776 NZ_CP035846:3437185-3437481 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118776 WP_000650107.1 NZ_CP035846:3437483-3437878 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118776 NZ_CP035846:3437483-3437878 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References