Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 903462..904306 Replicon chromosome
Accession NZ_CP035846
Organism Escherichia coli strain TW10598

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag EXA01_RS04450 Protein ID WP_000854686.1
Coordinates 903462..903845 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag EXA01_RS04455 Protein ID WP_001285602.1
Coordinates 903926..904306 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA01_RS04420 (900139) 900139..900843 + 705 WP_001241677.1 leucyl/phenylalanyl-tRNA--protein transferase -
EXA01_RS04425 (901128) 901128..901346 + 219 WP_001040187.1 translation initiation factor IF-1 -
EXA01_RS04435 (901836) 901836..902678 - 843 WP_001529751.1 DUF4942 domain-containing protein -
EXA01_RS04440 (902763) 902763..902960 - 198 WP_000839253.1 DUF957 domain-containing protein -
EXA01_RS04445 (902977) 902977..903465 - 489 WP_001054233.1 DUF5983 family protein -
EXA01_RS04450 (903462) 903462..903845 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
EXA01_RS04455 (903926) 903926..904306 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EXA01_RS04460 (904317) 904317..904694 - 378 WP_000271247.1 hypothetical protein -
EXA01_RS04465 (904867) 904867..905979 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
EXA01_RS04470 (906047) 906047..906349 - 303 Protein_883 hypothetical protein -
EXA01_RS04475 (906368) 906368..906589 - 222 WP_000692298.1 DUF987 domain-containing protein -
EXA01_RS04480 (906652) 906652..907128 - 477 WP_001186721.1 RadC family protein -
EXA01_RS04485 (907144) 907144..907629 - 486 WP_000214307.1 antirestriction protein -
EXA01_RS04490 (907721) 907721..908539 - 819 WP_001234726.1 DUF932 domain-containing protein -
EXA01_RS04495 (908639) 908639..908872 - 234 WP_001119717.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T118768 WP_000854686.1 NZ_CP035846:c903845-903462 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T118768 NZ_CP035846:c903845-903462 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT118768 WP_001285602.1 NZ_CP035846:c904306-903926 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT118768 NZ_CP035846:c904306-903926 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References