Detailed information of TA system TA118266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 576912..577459
• Replicon: chromosome
• Accession: NZ_CP035689
• Organism: Vibrio metoecus strain 08-2459

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EWA65_RS16340
• Protein ID: WP_095484351.1
• Coordinates: 576912..577214 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: EWA65_RS16345
• Protein ID: WP_000861987.1
• Coordinates: 577202..577459 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWA65_RS16295	572018..572200	-	183	Protein_599	DUF645 family protein	-
EWA65_RS16300	572495..572842	-	348	WP_055028416.1	hypothetical protein	-
EWA65_RS16305	573009..573290	-	282	WP_001912207.1	Dabb family protein	-
EWA65_RS16310	573453..573830	-	378	WP_000798826.1	hypothetical protein	-
EWA65_RS16315	573986..574399	-	414	WP_154139392.1	NUDIX domain-containing protein	-
EWA65_RS16320	574563..575513	-	951	WP_055028417.1	hypothetical protein	-
EWA65_RS16325	575720..575854	-	135	WP_095457862.1	DUF645 family protein	-
EWA65_RS16330	576087..576176	-	90	WP_171345239.1	DUF3265 domain-containing protein	-
EWA65_RS16335	576203..576835	-	633	WP_154139266.1	hypothetical protein	-
EWA65_RS16340	576912..577214	-	303	WP_095484351.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EWA65_RS16345	577202..577459	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EWA65_RS16355	577650..578225	-	576	WP_055028419.1	NAD(P)H-dependent oxidoreductase	-
EWA65_RS16360	578806..579171	-	366	WP_045629259.1	hypothetical protein	-
EWA65_RS16365	579309..580247	-	939	WP_154139268.1	hypothetical protein	-
EWA65_RS16370	580275..580400	-	126	WP_154139269.1	DUF3265 domain-containing protein	-
EWA65_RS16375	580411..580875	-	465	WP_038964939.1	ASCH domain-containing protein	-
EWA65_RS16380	581141..581377	+	237	WP_000772125.1	RNA-binding protein	-
EWA65_RS16385	581540..582019	-	480	WP_055028455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	453640..607302	153662
	-	inside	Integrative and Conjugative Element	-	hlyA	504927..845208	340281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11765.72 Da
• Isoelectric Point: 5.1972

>T118266 WP_095484351.1 NZ_CP035689:c577214-576912 [Vibrio metoecus]
MVEIIWTEPALSDLNDIVEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T118266 NZ_CP035689:c577214-576912 [Vibrio metoecus]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGTTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTTCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT118266 WP_000861987.1 NZ_CP035689:c577459-577202 [Vibrio metoecus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT118266 NZ_CP035689:c577459-577202 [Vibrio metoecus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9