Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 480685..481223 Replicon chromosome
Accession NZ_CP035689
Organism Vibrio metoecus strain 08-2459

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag EWA65_RS15395 Protein ID WP_000802131.1
Coordinates 480924..481223 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag EWA65_RS15390 Protein ID WP_002044787.1
Coordinates 480685..480927 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA65_RS15350 475867..476037 - 171 Protein_426 DUF645 family protein -
EWA65_RS15355 476353..476868 - 516 WP_055028427.1 hypothetical protein -
EWA65_RS15360 477014..477463 - 450 WP_001026799.1 GyrI-like domain-containing protein -
EWA65_RS15365 477577..477984 - 408 WP_095458993.1 hypothetical protein -
EWA65_RS15370 478201..478380 - 180 WP_055028422.1 DUF645 family protein -
EWA65_RS15375 478680..479258 - 579 WP_055028421.1 DJ-1/PfpI family protein -
EWA65_RS15380 479396..479929 - 534 WP_046268217.1 adenylate kinase -
EWA65_RS15385 480141..480350 - 210 Protein_433 DUF645 family protein -
EWA65_RS15390 480685..480927 + 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EWA65_RS15395 480924..481223 + 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EWA65_RS15400 481863..482636 - 774 WP_000350772.1 NERD domain-containing protein -
EWA65_RS15405 482780..483430 - 651 WP_055028428.1 hypothetical protein -
EWA65_RS15410 483630..483763 - 134 Protein_438 DUF645 family protein -
EWA65_RS15415 484112..484735 - 624 WP_154139235.1 DUF2026 family protein -
EWA65_RS15420 485006..485224 - 219 WP_044128180.1 DUF3709 domain-containing protein -
EWA65_RS15425 486009..486188 - 180 WP_154139236.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 453640..607302 153662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T118260 WP_000802131.1 NZ_CP035689:480924-481223 [Vibrio metoecus]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T118260 NZ_CP035689:480924-481223 [Vibrio metoecus]
ATGAAACCATTTAATCTTACAACTGCAGCCAAAACCGATTTGCGTGATATCGCTTTATTCACTCAACGCCGTTGGGGCAA
AGAGCAGAGAAACATCTACTTAAAGCAATTTGACGATTCATTTTGGCTTTTGGCTGAAAATCCCGACATCGGCAAATCAT
GTGATGAAATTCGAGATGGTTACCGTAAATTTCCTCAAGGTAGCCATGTGATTTTTTATCAGCAAACGGGCAGCCAACAG
ATTAGAGTCGTCCGTATTTTACATAAGAGCATGGATGTTAATCCGATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT118260 WP_002044787.1 NZ_CP035689:480685-480927 [Vibrio metoecus]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT118260 NZ_CP035689:480685-480927 [Vibrio metoecus]
ATGGCTAAGAACACAAGTATTACCCTTGGTGAACACTTTGATGGTTTTATCACAAACCAAATTCAAAGTGGGCGTTATGG
CTCTGCAAGTGAAGTCATTCGCTCAGCTTTGCGTTTACTCGAAAACCAAGAGACTAAACTGCAGACTCTCCGTCAACTAC
TTGTTGAAGGTGAACAAAGTGGTGACGCTGATTATGACCTTGATAGTTTCATCAATGAACTTGATAGTGAAACTAATCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References