Detailed information of TA system TA118246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2231424..2231971
• Replicon: chromosome
• Accession: NZ_CP035680
• Organism: Vibrio navarrensis strain 08-2462

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EWA66_RS11110
• Protein ID: WP_039443551.1
• Coordinates: 2231669..2231971 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B5V2P5
• Locus tag: EWA66_RS11105
• Protein ID: WP_000861988.1
• Coordinates: 2231424..2231681 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWA66_RS11060	2228042..2228197	+	156	WP_081947401.1	DUF3265 domain-containing protein	-
EWA66_RS11065	2228529..2228654	+	126	WP_019281455.1	DUF3265 domain-containing protein	-
EWA66_RS11070	2228698..2229180	+	483	WP_154199876.1	MazG-related protein	-
EWA66_RS11075	2229209..2229298	+	90	WP_072611516.1	DUF3265 domain-containing protein	-
EWA66_RS11080	2229316..2229612	+	297	WP_039445218.1	Dabb family protein	-
EWA66_RS11090	2230231..2230767	+	537	WP_000472590.1	GNAT family N-acetyltransferase	-
EWA66_RS20340	2230815..2230886	+	72	WP_195717884.1	hypothetical protein	-
EWA66_RS11100	2231217..2231342	+	126	WP_071919811.1	DUF3265 domain-containing protein	-
EWA66_RS11105	2231424..2231681	+	258	WP_000861988.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EWA66_RS11110	2231669..2231971	+	303	WP_039443551.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EWA66_RS11115	2232633..2233097	+	465	WP_039443553.1	GNAT family N-acetyltransferase	-
EWA66_RS11120	2233088..2233204	+	117	WP_081947344.1	DUF3265 domain-containing protein	-
EWA66_RS11125	2233236..2233733	+	498	WP_039443555.1	hypothetical protein	-
EWA66_RS11130	2233712..2233851	+	140	Protein_2088	DUF3265 domain-containing protein	-
EWA66_RS11135	2234212..2234334	+	123	WP_079753399.1	DUF3265 domain-containing protein	-
EWA66_RS11140	2234667..2234792	+	126	WP_081018692.1	DUF3265 domain-containing protein	-
EWA66_RS11145	2235152..2235271	+	120	Protein_2091	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1923154..2273696	350542
	-	flank	IS/Tn	-	-	2226711..2227526	815
	-	inside	Integron	-	-	2199675..2264089	64414

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11624.49 Da
• Isoelectric Point: 4.9061

>T118246 WP_039443551.1 NZ_CP035680:2231669-2231971 [Vibrio navarrensis]
MAEVIWTEPALSDLNEIAEYIALENVVAAKQLVQAIFSKVERLEVFPESGRIPPELEHLSYREVVANPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSRQ

Nucleotide

• Length: 303 bp

>T118246 NZ_CP035680:2231669-2231971 [Vibrio navarrensis]
ATGGCTGAAGTAATTTGGACTGAACCGGCGCTATCTGACCTAAATGAAATCGCTGAGTACATCGCGCTTGAAAATGTCGT
TGCTGCAAAGCAACTGGTTCAAGCAATCTTCTCGAAAGTCGAACGTCTAGAAGTTTTCCCAGAGTCAGGTCGTATTCCGC
CAGAATTAGAGCATTTGAGTTATCGTGAAGTTGTAGCAAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAGGTA
TTTATACTGTTTGTTATGCGCGCCGAGAGAGATTTGCGTAAGTTCTTGTTAAGTAGACAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9575.08 Da
• Isoelectric Point: 7.3177

>AT118246 WP_000861988.1 NZ_CP035680:2231424-2231681 [Vibrio navarrensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERAIADGKVVGHNEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT118246 NZ_CP035680:2231424-2231681 [Vibrio navarrensis]
ATGAAAGTAGAACTAGTTACATCGCTCAAACGGCAAGCAACCAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCCA
TTCTCGAAGGTATTGCACGAGGTGAACGCGCAATAGCTGACGGAAAGGTTGTTGGTCACAATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B5V2P5